Sökning: onr:"swepub:oai:DiVA.org:oru-64711" > RBBP6 increases rad...
Fältnamn | Indikatorer | Metadata |
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000 | 05969naa a2200553 4500 | |
001 | oai:DiVA.org:oru-64711 | |
003 | SwePub | |
008 | 180202s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-647112 URI |
024 | 7 | a https://doi.org/10.1111/cas.135162 DOI |
040 | a (SwePub)oru | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Xiao, Chaou Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut |
245 | 1 0 | a RBBP6 increases radioresistance and serves as a therapeutic target for preoperative radiotherapy in colorectal cancer |
264 | c 2018-03-10 | |
264 | 1 | b Blackwell Publishing,c 2018 |
338 | a print2 rdacarrier | |
520 | a Radiotherapy (RT) can be used as preoperative treatment to downstage initially unresectable locally rectal carcinoma, but the radioresistance and recurrence remain significant problems. Retinoblastoma binding protein 6 (RBBP6) has been implicated in the regulation of cell cycle, apoptosis and chemoresistance both in vitro and in vivo. This study investigated whether the inhibition of RBBP6 expression would improve radiosensitivity in human colorectal cancer cells. After SW620 and HT29 cells were exposed to radiation, the levels of RBBP6 mRNA and protein increased over time in both two cells. Moreover, a significant reduction in clonogenic survival and a decrease in cell viability in parallel with an obvious increase in cell apoptosis were demonstrated in irradiated RBBP6-knockdown cells. Besides, transfection with RBBP6 shRNA improved levels of G2-M phase arrest which blocked the cells in a more radiosensitive period of the cell cycle. These observations indicated that cell cycle and apoptosis mechanisms may be connected with tumor cell survival following radiotherapy. In vivo, tumor growth rate of nude mice in RBBP6-knockdown group was significantly slower than that in other groups. These results indicated that RBBP6 overexpression could resist colorectal cancer cells against radiation by regulating cell cycle and apoptosis pathways, and inhibition of RBBP6 could enhance radiosensitivity of human colorectal cancer. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Apoptosis | |
653 | a Cell cycle | |
653 | a Preoperative radiotherapy | |
653 | a RBBP6 | |
653 | a Rectal cancer | |
700 | 1 | a Wang, Yupengu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut |
700 | 1 | a Zheng, Miaou Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut |
700 | 1 | a Chen, Jianu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut |
700 | 1 | a Song, Guoheu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut |
700 | 1 | a Zhou, Zhijieu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut |
700 | 1 | a Zhou, Chongzhiu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut |
700 | 1 | a Sun, Xingu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut |
700 | 1 | a Zhong, Linu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut |
700 | 1 | a Ding, Erxunu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut |
700 | 1 | a Zhang, Yiu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut |
700 | 1 | a Yang, Liuu Department of Obstetrics and Gynecology, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut |
700 | 1 | a Wu, Gangu Department of General Surgery, Henan Provincial People's Hospital People's Hospital, Zhengzhou University, Zhengzhou, People's Republic of China4 aut |
700 | 1 | a Xu, Shifengu Department of General Surgery, Shandong Provincial Hospital Affiliated, Shandong University, Jinan, People's Republic of China4 aut |
700 | 1 | a Zhang, Hong,d 1957-u Örebro universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:oru)hzg |
700 | 1 | a Wang, Xiaoliangu Department of General Surgery, Shanghai General Hospital School of Medicine, Jiao Tong University, Shanghai, People's Republic of China4 aut |
710 | 2 | a Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of Chinab Department of Obstetrics and Gynecology, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 org |
773 | 0 | t Cancer Scienced : Blackwell Publishingg 109:4, s. 1075-1087q 109:4<1075-1087x 1347-9032x 1349-7006 |
856 | 4 | u https://doi.org/10.1111/cas.13516y Fulltext |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.13516 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-64711 |
856 | 4 8 | u https://doi.org/10.1111/cas.13516 |
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