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Non-digestible Poly...
Non-digestible Polysaccharides and Intestinal Barrier Function : specific focus on its efficacy in elderly and patients with Crohn’s disease
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- Ganda Mall, John-Peter, 1988- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Brummer, Robert Jan, professor, 1957- (preses)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Schoultz, Ida, PhD, 1979- (preses)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Keita, Åsa, PhD (preses)
- Linköping University
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- Wirén, Mikael, biträdande professor (opponent)
- Linköping University
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(creator_code:org_t)
- ISBN 9789175292465
- Örebro : Örebro University, 2018
- Engelska 121 s.
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Serie: Örebro Studies in Medicine, 1652-4063 ; 180
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Abstract
Ämnesord
Stäng
- A large number of elderly suffer from gastrointestinal (GI) symptoms such as constipation and diarrhoea. The underlying mechanisms of age-acquired GI symptoms are not well studied but are necessary to clarify in order to recommend the right treatment. Non-digestible polysaccharides (NPS) are dietary fibres that could have beneficial effects on the intestinal immune system and barrier function, although their efficacy needs to be evaluated. Paper I showed that elderly with GI symptoms have significantly higher small intestinal permeability than a general elderly population, along with a stronger association to psychological distress. In Paper II we performed a randomised controlled trial with a general population of elderly that consumed either placebo, the NPS’s arabinoxylan or oat β-glucan for a period of 6 weeks. No protective effects were observed related to indomethacin-induced intestinal hyperpermeability, inflammatory markers, or self-reported health if compared to placebo. Paper III showed that stimulation with a yeast-derived β-glucan significantly attenuated Compound (C) 48/80-induced hyperpermeability in colonic biopsies from elderly with GI symptoms mounted in Ussing chambers, but not in young healthy adults. Arabinoxylan attenuated only C48/80-induced transcellular permeability in elderly but both paracellular and transcellular permeability in young healthy adults. Paper IV showed that the same yeast-derived β-glucan from paper III could cross the epithelium of ileal tissues from patients with Crohn’s disease (CD) and non-CD controls, mounted in Ussing chambers, and attenuate C48/80-induced hyperpermeability. In conclusion, we found that elderly with GI symptoms display a deteriorated barrier function and that administration of selective NPS can have beneficial effect on intestinal permeability in selective populations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
Nyckelord
- Non-digestible polysachharides
- beta-glucan
- arabinoxylan
- barrier function
- permeability
- Ussing chamber
- elderly
- Crohn’s disease
Publikations- och innehållstyp
- vet (ämneskategori)
- dok (ämneskategori)
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