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Non-digestible Poly...
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Ganda Mall, John-Peter,1988-Örebro universitet,Institutionen för medicinska vetenskaper
(författare)
Non-digestible Polysaccharides and Intestinal Barrier Function : specific focus on its efficacy in elderly and patients with Crohn’s disease
Förlag, utgivningsår, omfång ...
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Örebro :Örebro University,2018
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121 s.
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-66055
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ISBN:9789175292465
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-66055URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:vet swepub-contenttype
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Ämneskategori:dok swepub-publicationtype
Serie
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Örebro Studies in Medicine,1652-4063 ;180
Anmärkningar
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A large number of elderly suffer from gastrointestinal (GI) symptoms such as constipation and diarrhoea. The underlying mechanisms of age-acquired GI symptoms are not well studied but are necessary to clarify in order to recommend the right treatment. Non-digestible polysaccharides (NPS) are dietary fibres that could have beneficial effects on the intestinal immune system and barrier function, although their efficacy needs to be evaluated. Paper I showed that elderly with GI symptoms have significantly higher small intestinal permeability than a general elderly population, along with a stronger association to psychological distress. In Paper II we performed a randomised controlled trial with a general population of elderly that consumed either placebo, the NPS’s arabinoxylan or oat β-glucan for a period of 6 weeks. No protective effects were observed related to indomethacin-induced intestinal hyperpermeability, inflammatory markers, or self-reported health if compared to placebo. Paper III showed that stimulation with a yeast-derived β-glucan significantly attenuated Compound (C) 48/80-induced hyperpermeability in colonic biopsies from elderly with GI symptoms mounted in Ussing chambers, but not in young healthy adults. Arabinoxylan attenuated only C48/80-induced transcellular permeability in elderly but both paracellular and transcellular permeability in young healthy adults. Paper IV showed that the same yeast-derived β-glucan from paper III could cross the epithelium of ileal tissues from patients with Crohn’s disease (CD) and non-CD controls, mounted in Ussing chambers, and attenuate C48/80-induced hyperpermeability. In conclusion, we found that elderly with GI symptoms display a deteriorated barrier function and that administration of selective NPS can have beneficial effect on intestinal permeability in selective populations.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Brummer, Robert Jan,professor,1957-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)rnbr
(preses)
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Schoultz, Ida,PhD,1979-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)isz
(preses)
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Keita, Åsa,PhDLinköping University
(preses)
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Wirén, Mikael,biträdande professorLinköping University
(opponent)
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Örebro universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
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