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TRIM24 as Independe...
TRIM24 as Independent Prognostic Marker in Prostate Cancer
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- Offermann, Anne (författare)
- University Medical Center Schleswig-Holstein, Leibniz Center for Medicine and Biosciences, Lübeck and Borstel, Germany
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- Schneider, Felix (författare)
- Klinik am Eicher Alb Fils Kliniken, Goeppingen, Germany
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- Hupe, Marie Christine (författare)
- University Hospital Schleswig-Holstein, Lübeck, Germany
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- Hohensteiner, Silke (författare)
- Klinik am Eichert Alb Fils Kliniken, Goeppingen, Germany
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- Becker, Finn (författare)
- University Medical Center Schleswig-Holstein, Leibniz Center for Medicine and Biosciences, Lübeck and Borstel, Germany
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- Carlsson, Jessica, 1984- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län
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- Kirfel, Jutta (författare)
- University Hospital Schleswig-Holstein, Leibniz Center for Medicine and Biosciences, Lübeck and Borstel, Germany
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- Svensson, Maria, 1980- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län
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- Andrén, Ove, 1963- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Merseburger, Axel (författare)
- University Hospital Lübeck, Lübeck, Germany
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- Lubczyk, Verena (författare)
- Klinik am Eichert Alb Fils Kliniken, Goeppingen, Germany
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- Kuefer, Rainer (författare)
- Klinik am Eichert Alb Fils Kliniken, Goeppingen, Germany
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- Sven, Perner (författare)
- University Medical Center Schleswig-Holstein, Leibniz Center for Medicine and Biosciences, Lübeck and Borstel, Germany, Lübeck
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(creator_code:org_t)
- Nature Publishing Group, 2018
- 2018
- Engelska.
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Ingår i: Modern Pathology. - : Nature Publishing Group. - 0893-3952 .- 1530-0285. ; 31:Suppl. 2, s. 372-373
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Simply applicable biomarkers for prostate cancer (PCa) predicting the clinical course are urgently needed. Recently, TRIM24 has been identified to promote androgen-receptor signaling and to correlate with poor outcome. Based on these data, we validated TRIM24 as a prognostic biomarker for PCa.Design: We performed TRIM24 immunohistochemistry on two independent cohorts including a total of 806 primary tumors, 26 locally advanced/recurrent tumors, 30 lymph node metastases, 30 distant metastases and 129 benign prostatic samples from 497 patients. Expression data were correlated with clinic-pathological data including biochemical recurrence free survival (bRFS) as endpoint.Results: Benign samples show no/low TRIM24 expression in 94%, while tumors demonstrate significantly higher levels. Strongest expression is observed in metastatic tumors. In multivariate analyses, TRIM24 up-regulation correlates with shorter bRFS independent of other prognostic parameters. 5-(10-) year bRFS rates for TRIM24 negative, low, medium and high expressing tumors are 93.1(93.1)%, 75.4(68.5)%, 54.9(47.5)% and 43.1(32.3)%, respectively. Of interest, tumors diagnosed as indolent disease, TRIM24 expression stratifies patients into specific risk groups. Increased TRIM24 expression associates with higher Grade Group, positive nodal status and extraprostatic tumor growth.Conclusions: Using two large independent cohorts, we found that TRIM24 expression predicts patients’ risk to develop disease recurrence with high accuracy and independently from other established prognostic markers. To our knowledge, TRIM24 is the first prognostic biomarker to be independent, accurate and reproducible on three different primary PCa cohorts. Thus, we strongly suggest introducing TRIM24 in clinical routine as a simple immunohistochemical test.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- vet (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Offermann, Anne
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Schneider, Felix
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Hupe, Marie Chri ...
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Hohensteiner, Si ...
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Becker, Finn
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Carlsson, Jessic ...
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Kirfel, Jutta
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Svensson, Maria, ...
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Andrén, Ove, 196 ...
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Merseburger, Axe ...
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Lubczyk, Verena
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Kuefer, Rainer
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Sven, Perner
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Modern Pathology
- Av lärosätet
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Örebro universitet