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Resuscitative endov...
Resuscitative endovascular balloon occlusion of the aorta : what is the optimum occlusion time in an ovine model of hemorrhagic shock?
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- Reva, V. A. (författare)
- Department of War Surgery, Kirov Military Medical Academy, Saint-Petersburg, Russian Federation
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- Matsumura, Y. (författare)
- R. Adams Cowley Shock Trauma Center, University of Maryland, Baltimore MD, United States; Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
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- Hörer, Tal M., 1971- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Cardiothoracic and Vascular Surgery, Örebro University Hospital, Örebro, Sweden
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- Sveklov, D. A. (författare)
- Department of War Surgery, Kirov Military Medical Academy, Saint-Petersburg, Russian Federation
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- Denisov, A. V. (författare)
- Department of War Surgery, Kirov Military Medical Academy, Saint-Petersburg, Russian Federation
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- Telickiy, S. Y. (författare)
- Department of War Surgery, Kirov Military Medical Academy, Saint-Petersburg, Russian Federation
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- Seleznev, A. B. (författare)
- Department of War Surgery, Kirov Military Medical Academy, Saint-Petersburg, Russian Federation
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- Bozhedomova, E. R. (författare)
- Department of War Surgery, Kirov Military Medical Academy, Saint-Petersburg, Russian Federation
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- Matsumoto, J. (författare)
- Departments of Emergency and Critical Care Medicine, Saint-Marianna University School of Medicine, Sugao Kawasaki, Japan; Department of Radiology, National Hospital Organization Disaster Medical Center, Tachikawa, Japan
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- Samokhvalov, I. M. (författare)
- Department of War Surgery, Kirov Military Medical Academy, Saint-Petersburg, Russian Federation
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- Morrison, J. J. (författare)
- Department of Vascular Surgery, South Glasgow University Hospital, Glasgow, United Kingdom; The Academic Department of Military Surgery and Trauma, Royal Centre for Defence Medicine, Birmingham, United Kingdom
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Department of War Surgery, Kirov Military Medical Academy, Saint-Petersburg, Russian Federation R Adams Cowley Shock Trauma Center, University of Maryland, Baltimore MD, United States; Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan (creator_code:org_t)
- 2016-10-13
- 2018
- Engelska.
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Ingår i: European Journal of Trauma and Emergency Surgery. - : Springer Berlin/Heidelberg. - 1863-9933 .- 1863-9941. ; 44:4, s. 511-518
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The aim of this study is to evaluate the early survival and organ damage following 30 and 60 min of thoracic resuscitative endovascular balloon occlusion of the aorta (REBOA) in an ovine model of severe hemorrhagic shock.Eighteen sheep were induced into shock by undergoing a 35 % controlled exsanguination over 30 min. Animals were randomized into three groups: 60-min REBOA 30 min after the bleeding (60-REBOA), 30-min REBOA 60 min after the bleeding (30-REBOA) and no-REBOA control (n-REBOA). Resuscitation with crystalloids and whole blood was initiated 20 and 80 min after the induction of shock. Animals were observed for 24 h with serial potassium and lactate measurements. Autopsy was performed to evaluate organ damage.Two animals of the n-REBOA group died within 90 min of shock induction; no hemorrhagic deaths were observed in the REBOA groups. Twenty-four-hour survival for the 60-, 30-, and n-REBOA groups was 0/6, 5/6, and 4/6 (P = 0.002). In 60-REBOA, potassium and lactate were increased at 270-min time point: from 4.3 to 5.1 mEq/l and from 3.7 to 5.1 mmol/L, respectively. Both these values were significantly higher than in the n-REBOA group (P = 0.029 for potassium and P = 0.039 for lactate). Autopsy revealed acute tubular necrosis in all died REBOA group animals.In this ovine model of severe hemorrhagic shock, REBOA can be used to prevent early death from hemorrhage; however, 60 min of occlusion results in significant metabolic derangement and organ damage that offsets this gain.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Resuscitative endovascular balloon occlusion of the aorta
- REBOA
- Hemorrhagic shock
- Ovine model
- Ischemia-reperfusion injury
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Reva, V. A.
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Matsumura, Y.
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Hörer, Tal M., 1 ...
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Sveklov, D. A.
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Denisov, A. V.
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Telickiy, S. Y.
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Seleznev, A. B.
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Bozhedomova, E. ...
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Matsumoto, J.
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Samokhvalov, I. ...
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Morrison, J. J.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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European Journal ...
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Örebro universitet