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Personalized treatm...
Personalized treatment of hepatitis C genotype 1a in Norway and Sweden 2014-2016 : a study of treatment outcome in patients with or without resistance-based DAA-therapy
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- Kileng, Hege (författare)
- Department of Clinical Medicine, Gastroenterology and Nutrition Research Group, UiT The Arctic University of Norway, Tromsø, Norway; Department of Medicine, University Hospital of North Norway, Tromsø, Norway
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- Kjellin, Midori (författare)
- Uppsala universitet,Klinisk mikrobiologi
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- Akaberi, Dario (författare)
- Uppsala universitet,Klinisk mikrobiologi
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- Bergfors, Assar (författare)
- Uppsala universitet,Klinisk mikrobiologi
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- Duberg, Ann-Sofi, Docent, 1957- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious Diseases
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- Wesslén, Lars (författare)
- Gävle Hospital, Gävle, Sweden
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- Danielsson, Astrid (författare)
- Falun Hospital, Falun, Sweden
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- Gangsøy Kristiansen, Magnhild (författare)
- Nordlandssykehuset Bodø, Department of Clinical Medicine (IKM), UiT The Artic University of Tromsø, Bodø, Norway
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- Gutteberg, Tore (författare)
- Department of Medical Biology, Research Group for Host-Microbe Interactions, UiT The Arctic University of Norway, Tromsø, Norway; Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway
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- Goll, Rasmus (författare)
- Department of Clinical Medicine, Gastroenterology and Nutrition Research Group, UiT The Arctic University of Norway, Tromsø, Norway; Department of Medicine, University Hospital of North Norway, Tromsø, Norway
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- Lannergård, Anders, 1953- (författare)
- Uppsala universitet,Infektionssjukdomar,Infektionsmedicin
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- Lennerstrand, Johan (författare)
- Uppsala universitet,Klinisk mikrobiologi
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(creator_code:org_t)
- 2018-11-05
- 2018
- Engelska.
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Ingår i: Scandinavian Journal of Gastroenterology. - : Taylor & Francis. - 0036-5521 .- 1502-7708. ; 53:10-11, s. 1347-1353
- Relaterad länk:
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https://doi.org/10.1...
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https://www.tandfonl...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: Resistance-associated substitutions (RASs) may impair treatment response to direct-acting antivirals (DAA) in hepatitis C virus (HCV) treatment. We investigated the effects of baseline NS3-RASs (Q80K and R155K) and clinically relevant NS5A-RASs in patients with HCV genotype (GT) 1a infection on treatment outcome, with or without resistance-based DAA-treatment. This multi-center study was carried out between 2014 and 2016.PATIENTS/METHODS: Treatment in the intervention group (n = 92) was tailored to baseline resistance. Detection of NS3-RAS led to an NS5A-inhibitor-based regimen and detection of NS5A-RAS to a protease-inhibitor regimen. Patients without baseline RAS in the intervention group and all patients in the control group (n = 101) received recommended standard DAA-treatment.RESULTS: The sustained virologic response rates (SVR) in the intervention and control groups were 97.8% (90/92) and 93.1% (94/101), respectively (p = .174). A trend toward higher SVR-rate in cirrhotic patients (p = .058) was noticed in the intervention group compared to the control group with SVR-rates 97.5% (39/40) and 83.3% (35/42), respectively. All patients with baseline NS3 (Q80K/R155K) or NS5A-RASs in the intervention group achieved SVR with personalized resistance-based treatment. In the control group, five patients with Q80K or R155K at baseline were treated with simeprevir + sofosbuvir and treatment failed in two of them. Furthermore, one of three patients who failed ledipasvir + sofosbuvir treatment had NS5A-RASs at baseline.CONCLUSIONS: In line with the findings of the OPTIMIST-2 trial for Q80K and the EASL-guidelines 2016 for NS5A-RASs, baseline RASs appeared to have an impact on treatment outcome albeit a statistical significance was not observed in this low-prevalence population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Baseline resistance
- NS5A
- Q80K
- hepatitis C virus
- resistance-associated substitution
- sustained virologic response
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Kileng, Hege
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Kjellin, Midori
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Akaberi, Dario
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Bergfors, Assar
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Duberg, Ann-Sofi ...
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Wesslén, Lars
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Danielsson, Astr ...
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Gangsøy Kristian ...
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Gutteberg, Tore
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Goll, Rasmus
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Lannergård, Ande ...
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Lennerstrand, Jo ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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Scandinavian Jou ...
- Av lärosätet
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Örebro universitet
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Uppsala universitet