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Anxiety after coeli...
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Ludvigsson, Jonas F.,1969-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, City Hospital, Nottingham, UK; Department of Medicine, Celiac Disease Center, Columbia University College of Physicians and Surgeons, New York City, USA
(författare)
Anxiety after coeliac disease diagnosis predicts mucosal healing : a population-based study
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2018-10-04
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John Wiley & Sons,2018
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:oru-70301
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-70301URI
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https://doi.org/10.1111/apt.14991DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:139537561URI
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Språk:engelska
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Sammanfattning på:engelska
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Funding Agency:Örebro University Hospital
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Background: Coeliac disease has been linked to anxiety and depression. However, their association with mucosal healing is unknown.Aim: To examine the relationship between anxiety, depression and mucosal healing in coeliac disease.Methods: Between 1969 and 2008, we collected data on all small intestinal biopsies with villous atrophy from Sweden's 28 pathology departments. We restricted our cohort to individuals with data on follow-up biopsy (either persistent villous atrophy [n = 3317] or mucosal healing [n = 4331]). Through Cox regression, we estimated hazard ratios (HRs) for anxiety or depression.Results: Conclusion APPENDIX During follow-up, 123 (2.8/1000 person-years) individuals with mucosal healing had developed anxiety, compared to 94 (2.1/1000 person-years) with persistent villous atrophy. Mucosal healing was hence associated with a higher risk of future anxiety (HR = 1.49; 95% CI = 1.12-1.96). Similarly, 167 (3.8/1000 person-years) individuals with mucosal healing developed depression, compared to 148 (3.3/1000 person-years) with persistent villous atrophy, corresponding to a HR of 1.25 (95% CI = 0.99-1.59). Mucosal healing was more common in individuals with prior diagnoses of anxiety or depression before follow-up biopsy. Anxiety diagnosed between diagnostic and follow-up biopsy for coeliac disease was associated with an almost nine-fold increased chance of mucosal healing (odds ratio = 8.94; 95%CI = 2.03-39.27).Conclusion: Anxiety and depression are more common in coeliac disease patients with mucosal healing, both before and after follow-up biopsy, an association potentially mediated through more vigilant compliance with a gluten-free diet. This finding raises concern that achieving the goal of mucosal healing may come at a cost of an increased risk of mood disorders.
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Lebwohl, BenjaminDepartment of Medicine, Celiac Disease Center, Columbia University College of Physicians and Surgeons, New York City, USA
(författare)
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Chen, QiKarolinska Institutet
(författare)
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Bröms, GabriellaKarolinska Institutet
(författare)
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Wolf, Randi L.Department of Health & Behavior Studies, Program in Nutrition, Teachers College, Columbia University, New York City, USA
(författare)
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Green, Peter H. R.Department of Medicine, Celiac Disease Center, Columbia University College of Physicians and Surgeons, New York City, USA
(författare)
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Emilsson, LouiseDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston Massachusetts, USA; Department of Health Management and Health Economy, Institute of Health and Society, University of Oslo, Oslo, Norway; Centre for Clinical Research, Vårdcentralen Värmlands Nysäter, Värmlands Nysäter, Sweden
(författare)
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Örebro universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Alimentary Pharmacology and Therapeutics: John Wiley & Sons48:10, s. 1091-10980269-28131365-2036
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