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Blocking VLDL secre...
Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice
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- Minehira, Kaori (författare)
- Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA, USA; Department of Physiology, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
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- Young, Stephen G. (författare)
- Department of Medicine, University of California, Los Angeles, CA, USA
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- Villanueva, Claudio J (författare)
- Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA, USA
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- Yetukuri, Laxman (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Oresic, Matej, 1967- (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Hellerstein, Mark K. (författare)
- Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA, USA
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- Farese, Robert V., Jr (författare)
- Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA, USA
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- Horton, Jay D (författare)
- Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA
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- Preitner, Frederic (författare)
- Department of Physiology, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
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- Thorens, Bernard (författare)
- Department of Physiology, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
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- Tappy, Luc (författare)
- Department of Physiology, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
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(creator_code:org_t)
- American Society for Biochemistry and Molecular Biology, 2008
- 2008
- Engelska.
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Ingår i: Journal of Lipid Research. - : American Society for Biochemistry and Molecular Biology. - 0022-2275 .- 1539-7262. ; 49:9, s. 2038-2044
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The liver secretes triglyceride-rich VLDLs, and the triglycerides in these particles are taken up by peripheral tissues, mainly heart, skeletal muscle, and adipose tissue. Blocking hepatic VLDL secretion interferes with the delivery of liver-derived triglycerides to peripheral tissues and results in an accumulation of triglycerides in the liver. However, it is unclear how interfering with hepatic triglyceride secretion affects adiposity, muscle triglyceride stores, and insulin sensitivity. To explore these issues, we examined mice that cannot secrete VLDL [due to the absence of microsomal triglyceride transfer protein (Mttp) in the liver]. These mice exhibit markedly reduced levels of apolipoprotein B-100 in the plasma, along with reduced levels of triglycerides in the plasma. Despite the low plasma triglyceride levels, triglyceride levels in skeletal muscle were unaffected. Adiposity and adipose tissue triglyceride synthesis rates were also normal, and body weight curves were unaffected. Even though the blockade of VLDL secretion caused hepatic steatosis accompanied by increased ceramides and diacylglycerols in the liver, the mice exhibited normal glucose tolerance and were sensitive to insulin at the whole-body level, as judged by hyperinsulinemic euglycemic clamp studies. Normal hepatic glucose production and insulin signaling were also maintained in the fatty liver induced by Mttp deletion. Thus, blocking VLDL secretion causes hepatic steatosis without insulin resistance, and there is little effect on muscle triglyceride stores or adiposity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
Nyckelord
- Microsomal triglyceride transfer protein
- triglyceride-rich lipoprotein
- fatty liver
- insulin resistance
- obesity
- de novo lipogenesis
- ceramide
- diacylglycerol
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Minehira, Kaori
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Young, Stephen G ...
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Villanueva, Clau ...
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Yetukuri, Laxman
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Oresic, Matej, 1 ...
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Hellerstein, Mar ...
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visa fler...
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Farese, Robert V ...
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Horton, Jay D
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Preitner, Freder ...
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Thorens, Bernard
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Tappy, Luc
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Andra medicinska ...
- Artiklar i publikationen
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Journal of Lipid ...
- Av lärosätet
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Örebro universitet