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Fatty fish intake d...
Fatty fish intake decreases lipids related to inflammation and insulin signaling : a lipidomics approach
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- Lankinen, Maria (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland; Department of Clinical Nutrition, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
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- Schwab, Ursula (författare)
- Department of Clinical Nutrition, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland; Department of Internal Medicine, Kuopio University Hospital, Kuopio, Finland
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- Erkkilä, Arja (författare)
- Department of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
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- Seppänen-Laakso, Tuulikki (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Hannila, Marja-Leena (författare)
- Information Technology Centre, University of Kuopio, Kuopio, Finland
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- Mussalo, Hanna (författare)
- Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
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- Lehto, Seppo (författare)
- Department of Internal Medicine, Kuopio University Hospital, Kuopio, Finland
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- Uusitupa, Matti (författare)
- Department of Clinical Nutrition, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
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- Gylling, Helena (författare)
- Department of Clinical Nutrition, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland; Department of Internal Medicine, Kuopio University Hospital, Kuopio, Finland
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- Oresic, Matej, 1967- (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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(creator_code:org_t)
- 2009-04-23
- 2009
- Engelska.
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Ingår i: PLOS ONE. - : PLOS. - 1932-6203. ; 4:4
- Relaterad länk:
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https://doi.org/10.1...
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The evidence of the multiple beneficial health effects of fish consumption is strong, but physiological mechanisms behind these effects are not completely known. Little information is available on the effects of consumption of different type of fish. The aim of this study was to investigate how fatty fish or lean fish in a diet affect serum lipidomic profiles in subjects with coronary heart disease.METHODOLOGY AND PRINCIPAL FINDINGS: A pilot study was designed which included altogether 33 subjects with myocardial infarction or unstable ischemic attack in an 8-week parallel controlled intervention. The subjects were randomized to either fatty fish (n = 11), lean fish (n = 12) or control (n = 10) groups. Subjects in the fish groups had 4 fish meals per week and subjects in the control group consumed lean beef, pork and chicken. A fish meal was allowed once a week maximum. Lipidomics analyses were performed using ultra performance liquid chromatography coupled to electrospray ionization mass spectrometry and gas chromatography. Multiple bioactive lipid species, including ceramides, lysophosphatidylcholines and diacylglycerols, decreased significantly in the fatty fish group, whereas in the lean fish group cholesterol esters and specific long-chain triacylglycerols increased significantly (False Discovery Rate q-value <0.05).CONCLUSIONS/SIGNIFICANCE: The 8-week consumption of fatty fish decreased lipids which are potential mediators of lipid-induced insulin resistance and inflammation, and may be related to the protective effects of fatty fish on the progression of atherosclerotic vascular diseases or insulin resistance.TRIAL REGISTRATION: ClinicalTrials.gov NCT00720655.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Lankinen, Maria
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Schwab, Ursula
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Erkkilä, Arja
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Seppänen-Laakso, ...
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Hannila, Marja-L ...
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Mussalo, Hanna
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visa fler...
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Lehto, Seppo
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Uusitupa, Matti
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Gylling, Helena
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Oresic, Matej, 1 ...
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Örebro universitet