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Link between plasma...
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de Mello, V. D. F.Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
(författare)
Link between plasma ceramides, inflammation and insulin resistance : association with serum IL-6 concentration in patients with coronary heart disease
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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2009-08-11
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Springer,2009
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LIBRIS-ID:oai:DiVA.org:oru-70945
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-70945URI
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https://doi.org/10.1007/s00125-009-1482-9DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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AIMS/HYPOTHESIS: Ceramides and IL-6 have a role in immune-inflammatory responses and cardiovascular diseases, and are suggested to be involved in insulin and glucose metabolism. We sought to assess the associations of circulating levels of IL-6, TNF-alpha and high-sensitivity C reactive protein (hsCRP), which are inflammatory markers related to insulin resistance (IR), with the plasma lipid metabolites ceramides and diacylglycerols (DAG) in patients with CHD.METHODS: Cross-sectional analyses were carried out on data from 33 patients with CHD. Serum levels of the inflammatory markers and plasma lipid metabolites (lipidomics approach performed by ultra-performance liquid chromatography coupled to electrospray ionisation MS) were measured at the same time point as insulin resistance (IR) (HOMA-IR index).RESULTS: Serum circulating levels of IL-6 were strongly correlated with plasma ceramide concentrations (r = 0.59, p < 0.001). Adjustments for serum TNF-alpha or hsCRP levels, smoking, BMI, age, sex or HOMA-IR did not change the results (p < 0.001). After adjustments for the effect of serum inflammatory markers (TNF-alpha or hsCRP), HOMA-IR and BMI the correlation between plasma DAG and serum IL-6 (r = 0.33) was also significant (p < 0.03). In a linear regression model, circulating levels of both ceramides and TNF-alpha had a significant independent influence on circulating levels of IL-6, altogether accounting for 41% of its variation (p < 0.001).CONCLUSIONS/INTERPRETATION: Our results strongly suggest that the link between ceramides, IR and inflammation is related to the inflammatory marker IL-6. Ceramides may contribute to the induction of inflammation involved in IR states that frequently coexist with CHD.
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Lankinen, M.Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland; VTT Technical Research Centre of Finland, Espoo, Finland
(författare)
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Schwab, U.Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland; Department of Internal Medicine, Kuopio University Hospital, Kuopio, Finland
(författare)
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Kolehmainen, M.Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
(författare)
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Lehto, S.Department of Internal Medicine, Kuopio University Hospital, Kuopio, Finland
(författare)
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Seppänen-Laakso, T.VTT Technical Research Centre of Finland, Espoo, Finland
(författare)
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Oresic, Matej,1967-VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)moc
(författare)
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Pulkkinen, L.Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
(författare)
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Uusitupa, MDepartment of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
(författare)
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Erkkilä, A. T.Department of Public Health, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
(författare)
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Department of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, FinlandDepartment of Clinical Nutrition/Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland; VTT Technical Research Centre of Finland, Espoo, Finland
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetologia: Springer52:12, s. 2612-26150012-186X1432-0428
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de Mello, V. D. ...
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Lankinen, M.
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Schwab, U.
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Kolehmainen, M.
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Lehto, S.
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Seppänen-Laakso, ...
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visa fler...
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Oresic, Matej, 1 ...
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Pulkkinen, L.
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Uusitupa, M
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Erkkilä, A. T.
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