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Tick-borne encephal...
Tick-borne encephalitis (TBE) vaccine failures : A ten-year retrospective study supporting the rationale for adding an extra priming dose in individuals from the age of 50 years
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- Hansson, Karin (författare)
- Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Department of Infectious diseases, Södersjukhuset, Stockholm, Sweden
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- Rosdahl, Anja, 1972- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious Diseases, Örebro University Hospital, Örebro, Sweden
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- Insulander, Mona (författare)
- Department of Communicable Disease Control and Prevention, Stockholm County, Stockholm, Sweden
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- Vene, Sirkka (författare)
- Public Health Agency of Sweden, Solna, Sweden
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- Lindquist, Lars (författare)
- Department of Medicine, Karolinska Institutet, Stockholm, Huddinge, Sweden; Department of Infectious diseases, Karolinska University Hospital, Stockholm, Sweden
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- Gredmark-Russ, Sara (författare)
- Karolinska Institutet
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- Askling, Helena H. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2019-03-07
- 2020
- Engelska.
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Ingår i: Clinical Infectious Diseases. - : Oxford University Press. - 1058-4838 .- 1537-6591. ; 70:2, s. 245-251
- Relaterad länk:
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https://doi.org/10.1...
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Southern Sweden is endemic for tick borne encephalitis (TBE), with Stockholm County as one of the high-risk areas. The aim of this study was to describe cases of vaccine failures, and to optimize future vaccination recommendations.METHODS: Patients with TBE were identified in the notification database at the Department of Communicable Disease Control and Prevention in the county of Stockholm during 2006-2015. Vaccine failure was defined as TBE despite adherence to the recommended vaccination schedule with at least two doses. Clinical data were extracted from medical records.RESULTS: A total of 1004 TBE cases were identified, 53 (5%) were defined as vaccine failures. In this latter group the median age was 62 years (6-83). Forty-three (81%) patients were over 50 years of age and two were children. Approximately half of the patients had comorbidities with diseases affecting the immune system accounting for 26% of all cases.Vaccine failures following the third or fourth vaccine dose accounted for 36 (68%) of the patients. Severe and moderate TBE disease affected 81% of the cases.CONCLUSION: To our knowledge, this is the largest documented cohort of TBE-vaccine failures. Vaccine failure after five TBE-vaccine doses is rare. Our data provides rationale for adding an extra priming dose to the age group 50 years and older.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- TBE
- TBEV
- vaccination
- vaccine failure
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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