Sökning: onr:"swepub:oai:DiVA.org:oru-78629" >
The familial co-agg...
The familial co-aggregation of stress-related disorders and autoimmune diseases
-
- Song, Huan (författare)
- Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
-
- Yao, Yuyang (författare)
- Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden
-
- Fang, Fang (författare)
- Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden
-
visa fler...
-
- Lichtenstein, Paul (författare)
- Karolinska Institutet, Stockholm, Sweden
-
- D'Onofrio, Brian (författare)
- Indiana University, Bloomingto IN, USA
-
- Almqvist, Catarina (författare)
- Karolinska Institutet, Stockholm, Sweden
-
- Larsson, Henrik, 1975- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
-
- Valdimarsdottir, Unnur (författare)
- Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
-
visa färre...
-
(creator_code:org_t)
- 2019-10-22
- 2019
- Engelska.
-
Ingår i: Behavior Genetics. - : Springer. - 0001-8244 .- 1573-3297. ; 49:6, s. 539-540
- Relaterad länk:
-
https://scholarlypub...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Evidence has emerged indicating a role of stress-related disorders in the development of autoimmune diseases. However, it remains unknown whether genetic components contribute to the observed association. We therefore investigated the co-aggregation of stress-related disorders and autoimmune diseases in individuals and their family members in the Swedish population.Methods: We identified 4,123,631 individuals born in Sweden between 1953 and 1993. Based on information from the Multi-Generation Register, we conducted cohorts of relatives of varying relatedness. Logistic regression was used to estimate the association between clinical ascertained stress-related disorders (i.e., acute stress reaction, posttraumatic stress disorder [PTSD], adjustment disorder, and other severe stress reactions) and autoimmune diseases (36 different types) in individuals and in families, presenting relative risks as odds ratios (ORs).Results: Individuals with stress-related disorder were at high er risk of having autoimmune diseases compared with individuals who did nothave stress-related disorder (OR = 1.66, 95% confidence intervals (CI) 1.63–1.69). Within families, the association seemed strongest between monozygotic twins (OR = 1.47, 95% CI 1.07–2.03), and then decreased with descending dyads of familial/genetic relatedness ̄OR was 1.28 (95% CI 0.97–1.67), 1.16 (95% CI 1.14–1.18), 1.05 (95% CI 1.02–1.09), 1.06 (95% CI 1.03–1.10), 1.05 (95% CI 1.04–1.06), and 1.00 (95% CI 0.98–1.04) for dizygotic twins, full siblings, maternal half siblings, paternal half siblings, full cousins, and half cousins, respectively. Further analyses on PTSD and autoimmune diseases obtained similar estimates.Conclusion: The pattern of the association across twin zygosity and varying familial relatedness supports the hypothesis of a genetic overlap between stress-related disorders and autoimmune diseases which warrants further exploration.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Publikations- och innehållstyp
- vet (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas