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Comorbidity of subs...
Comorbidity of substance misuse with anxiety-related and depressive disorders : a genetically informative population study of 3 million individuals in Sweden
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- Virtanen, Suvi (författare)
- Karolinska Institutet
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- Kuja-Halkola, Ralf (författare)
- Karolinska Institutet
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- Mataix-Cols, David (författare)
- Karolinska Institutet
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- Jayaram-Lindström, Nitya (författare)
- Karolinska Institutet
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- D'Onofrio, Brian M. (författare)
- Karolinska Institutet
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- Larsson, Henrik, 1975- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Rück, Christian (författare)
- Karolinska Institutet
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- Suvisaari, Jaana (författare)
- National Institute for Health and Welfare, Helsinki, Finland
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- Lichtenstein, Paul (författare)
- Karolinska Institutet
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- Latvala, Antti (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Cambridge University Press, 2020
- 2020
- Engelska.
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Ingår i: Psychological Medicine. - : Cambridge University Press. - 0033-2917 .- 1469-8978. ; 50:10, s. 1706-1715
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Causes of the comorbidity of substance misuse with anxiety-related and depressive disorders (anxiety/depression) remain poorly known. We estimated associations of substance misuse and anxiety/depression in the general population and tested them while accounting for genetic and shared environmental factors.METHODS: We studied individuals born in Sweden 1968-1997 (n = 2 996 398) with follow-up in nationwide register data for 1997-2013. To account for familial effects, stratified analyses were conducted within siblings and twin pairs. Substance misuse was defined as ICD-10 alcohol or drug use disorder or an alcohol/drug-related criminal conviction. Three dimensions of ICD-10 anxiety and depressive disorders and a substance misuse dimension were identified through exploratory factor analysis.RESULTS: Substance misuse was associated with a 4.5-fold (95% CI 4.50-4.58) elevated risk of lifetime generalized anxiety/depression, 4.7-fold (95% CI 4.63-4.82) elevated risk of panic disorder and agora/social phobia, and 2.9-fold elevated risk of phobias/OCD (95% CI 2.82-3.02) as compared to those without substance misuse. The associations were attenuated in within-family analyses but we found elevated risks in monozygotic twin pairs discordant for substance misuse as well as significant non-shared environmental correlations. The association between anxiety/depression and substance misuse was mainly driven by generalized anxiety/depression, whereas other anxiety/depression dimensions had minor or no independent associations with substance misuse.CONCLUSIONS: Substance misuse and anxiety/depression are associated at the population level, and these associations are partially explained by familial liabilities. Our findings indicate a common genetic etiology but are also compatible with a potential partially causal relationship between substance misuse and anxiety/depression.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Alcohol
- anxiety
- cohort
- depression
- drug
- family study
- genetic
- substance use
- twins
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Virtanen, Suvi
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Kuja-Halkola, Ra ...
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Mataix-Cols, Dav ...
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Jayaram-Lindströ ...
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D'Onofrio, Brian ...
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Larsson, Henrik, ...
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visa fler...
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Rück, Christian
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Suvisaari, Jaana
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Lichtenstein, Pa ...
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Latvala, Antti
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
- Artiklar i publikationen
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Psychological Me ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet