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Heat Shock Factor 5...
Heat Shock Factor 5 Is Essential for Spermatogenesis in Zebrafish
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- Saju, Jolly M. (författare)
- Reproductive Genomics Group, Temasek Life Sciences Laboratory, Singapore, Singapore
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- Hossain, Mohammad Sorowar (författare)
- Reproductive Genomics Group, Temasek Life Sciences Laboratory, Singapore, Singapore; Department of Biological Sciences, National University of Singapore, Singapore, Singapore
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- Liew, Woei Chang (författare)
- Reproductive Genomics Group, Temasek Life Sciences Laboratory, Singapore, Singapore
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- Pradhan, Ajay, 1983- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Thevasagayam, Natascha May (författare)
- Reproductive Genomics Group, Temasek Life Sciences Laboratory, Singapore, Singapore
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- Tan, Lydia Shun En (författare)
- Reproductive Genomics Group, Temasek Life Sciences Laboratory, Singapore, Singapore
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- Anand, Amit (författare)
- Bioimaging and Biocomputing, Temasek Life Sciences Laboratory, Singapore, Singapore
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- Olsson, Per-Erik, 1957- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Orbán, László (författare)
- Reproductive Genomics Group, Temasek Life Sciences Laboratory, Singapore, Singapore; Frontline Fish Genomics Research Group, Department of Animal Sciences, Georgikon Faculty, University of Pannonia, Keszthely, Hungary; Centre for Comparative Genomics, Murdoch University, Murdoch, Australia
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(creator_code:org_t)
- Cell Press, 2018
- 2018
- Engelska.
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Ingår i: Cell Reports. - : Cell Press. - 2211-1247. ; 25:12, s. 3252-3261
- Relaterad länk:
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https://doi.org/10.1...
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https://oru.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Heat shock factors (Hsfs) are transcription factors that regulate responses to heat shock and other environmental stimuli. Four heat shock factors (Hsf1-4) have been characterized from vertebrates to date. In addition to stress response, they also play important roles in development and gametogenesis. Here, we study the fifth member of heat shock factor family, Hsf5, using zebrafish as a model organism. Mutant hsf5(-/-) males, generated by CRISPR/Cas9 technique, were infertile with drastically reduced sperm count, increased sperm head size, and abnormal tail architecture, whereas females remained fertile. We show that Hsf5 is required for progression through meiotic prophase 1 during spermatogenesis as suggested by the accumulation of cells in the leptotene and zygotene-pachytene stages and increased apoptosis in post-meiotic cells. hsf5(-/-) mutants show gonadal misregulation of a substantial number of genes with roles in cell cycle, apoptosis, protein modifications, and signal transduction, indicating an important role of Hsf5 in early stages of spermatogenesis.
Ämnesord
- NATURVETENSKAP -- Biologi -- Utvecklingsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Developmental Biology (hsv//eng)
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- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Saju, Jolly M.
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Hossain, Mohamma ...
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Liew, Woei Chang
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Pradhan, Ajay, 1 ...
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Thevasagayam, Na ...
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Tan, Lydia Shun ...
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visa fler...
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Anand, Amit
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Olsson, Per-Erik ...
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Orbán, László
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Utvecklingsbiolo ...
- Artiklar i publikationen
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Cell Reports
- Av lärosätet
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Örebro universitet