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Pregnancy Associate...
Pregnancy Associated Plasma Protein-A as a Cardiovascular Risk Marker in Patients with Stable Coronary Heart Disease During 10 Years Follow-Up-A CLARICOR Trial Sub-Study
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- Nilsson, Erik, 1975- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,School of Medical Sciences, Örebro University, 70182 Örebro, Sweden.
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- Kastrup, Jens (författare)
- Department of Cardiology, Rigshospitalet University of Copenhagen, 2100 Copenhagen, Denmark.
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- Sajadieh, Ahmad (författare)
- Department of Cardiology, Copenhagen University Hospital of Bispebjerg and Frederiksberg, 2000 Frederiksberg, Denmark.
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- Jensen, Gorm Boje (författare)
- Department of Cardiology, Hvidovre Hospital University of Copenhagen, 2650 Hvidovre, Denmark.
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- Kjøller, Erik (författare)
- Department of Cardiology S, Herlev Hospital University of Copenhagen, Herlev, Denmark; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark,Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
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- Kolmos, Hans Jørn (författare)
- Department of Clinical Microbiology, Odense University Hospital, 5000 Odense, Denmark.
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- Wuopio, Jonas (författare)
- Department of Medicine, Mora County Hospital, 79251 Mora, Sweden.
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- Nowak, Christoph (författare)
- Karolinska Institutet
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- Larsson, Anders (författare)
- Karolinska Institutet,Uppsala universitet,Klinisk kemi
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- Jakobsen, Janus Christian (författare)
- Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Cardiology, Holbæk Hospital, Holbæk, Denmark,Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
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- Winkel, Per (författare)
- Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
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- Gluud, Christian (författare)
- Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
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- Iversen, Kasper K. (författare)
- Department of Cardiology S, Herlev Hospital University of Copenhagen, 2730 Herlev, Denmark.
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- Ärnlöv, Johan, 1970- (författare)
- Karolinska Institutet,Högskolan Dalarna,Medicinsk vetenskap,Division for Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 14183 Huddinge, Sweden.
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- Carlsson, Axel C. (författare)
- Division for Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 14183 Huddinge, Sweden.
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(creator_code:org_t)
- 2020-01-18
- 2020
- Engelska.
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Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 9:1
- Relaterad länk:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://du.diva-port... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Elevated pregnancy-associated plasma protein A (PAPP-A) is associated with mortality in acute coronary syndromes. Few studies have assessed PAPP-A in stable coronary artery disease (CAD) and results are conflicting. We assessed the 10-year prognostic relevance of PAPP-A levels in stable CAD. The CLARICOR trial was a randomized controlled clinical trial including outpatients with stable CAD, randomized to clarithromycin versus placebo. The placebo group constituted our discovery cohort (n = 1.996) and the clarithromycin group the replication cohort (n = 1.975). The composite primary outcome was first occurrence of cardiovascular event or death. In the discovery cohort, incidence rates (IR) for the composite outcome were higher in those with elevated PAPP-A (IR 12.72, 95% Confidence Interval (CI) 11.0-14.7 events/100 years) compared to lower PAPP-A (IR 8.78, 8.25-9.34), with comparable results in the replication cohort. Elevated PAPP-A was associated with increased risk of the composite outcome in both cohorts (discovery Hazard Ratio (HR) 1.45, 95% CI 1.24-1.70; replication HR 1.29, 95% CI 1.10-1.52). In models adjusted for established risk factors, these trends were attenuated. Elevated PAPP-A was associated with higher all-cause mortality in both cohorts. We conclude that elevated PAPP-A levels are associated with increased long-term mortality in stable CAD, but do not improve long-term prediction of death or cardiovascular events when added to established predictors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- pregnancy-associated plasma protein-A
- coronary artery disease
- cohort studies
- biomarkers
- Health and Welfare
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Nilsson, Erik, 1 ...
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Kastrup, Jens
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Sajadieh, Ahmad
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Jensen, Gorm Boj ...
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Kjøller, Erik
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Kolmos, Hans Jør ...
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visa fler...
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Wuopio, Jonas
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Nowak, Christoph
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Larsson, Anders
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Jakobsen, Janus ...
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Winkel, Per
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Gluud, Christian
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Iversen, Kasper ...
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Ärnlöv, Johan, 1 ...
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Carlsson, Axel C ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Journal of Clini ...
- Av lärosätet
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Örebro universitet
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Högskolan Dalarna
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Uppsala universitet
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Karolinska Institutet