Sökning: onr:"swepub:oai:DiVA.org:oru-80677" > Pregnancy Associate...
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001 | oai:DiVA.org:oru-80677 | |
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024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-806772 URI |
024 | 7 | a https://doi.org/10.3390/jcm90102652 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:du-317342 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4036792 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1430566862 URI |
040 | a (SwePub)orud (SwePub)dud (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Nilsson, Erik,d 1975-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,School of Medical Sciences, Örebro University, 70182 Örebro, Sweden.4 aut0 (Swepub:oru)eans |
245 | 1 0 | a Pregnancy Associated Plasma Protein-A as a Cardiovascular Risk Marker in Patients with Stable Coronary Heart Disease During 10 Years Follow-Up-A CLARICOR Trial Sub-Study |
264 | c 2020-01-18 | |
264 | 1 | b MDPI,c 2020 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies:Copenhagen Trial Unit, Centre for Clinical Intervention Research Danish Heart Foundation 01-1-5-21-22894 99-2-5-103-22773 99-1-5-87-22712 97-2-5-70-22537Copenhagen Hospital Corporation Det Frie Forskningsrad (DFF) 9702122 22-00-0261The 1991 Pharmacy Foundation HPN/ld/71-97Copenhagen Trial Unit | |
520 | a Elevated pregnancy-associated plasma protein A (PAPP-A) is associated with mortality in acute coronary syndromes. Few studies have assessed PAPP-A in stable coronary artery disease (CAD) and results are conflicting. We assessed the 10-year prognostic relevance of PAPP-A levels in stable CAD. The CLARICOR trial was a randomized controlled clinical trial including outpatients with stable CAD, randomized to clarithromycin versus placebo. The placebo group constituted our discovery cohort (n = 1.996) and the clarithromycin group the replication cohort (n = 1.975). The composite primary outcome was first occurrence of cardiovascular event or death. In the discovery cohort, incidence rates (IR) for the composite outcome were higher in those with elevated PAPP-A (IR 12.72, 95% Confidence Interval (CI) 11.0-14.7 events/100 years) compared to lower PAPP-A (IR 8.78, 8.25-9.34), with comparable results in the replication cohort. Elevated PAPP-A was associated with increased risk of the composite outcome in both cohorts (discovery Hazard Ratio (HR) 1.45, 95% CI 1.24-1.70; replication HR 1.29, 95% CI 1.10-1.52). In models adjusted for established risk factors, these trends were attenuated. Elevated PAPP-A was associated with higher all-cause mortality in both cohorts. We conclude that elevated PAPP-A levels are associated with increased long-term mortality in stable CAD, but do not improve long-term prediction of death or cardiovascular events when added to established predictors. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
653 | a pregnancy-associated plasma protein-A | |
653 | a coronary artery disease | |
653 | a cohort studies | |
653 | a biomarkers | |
653 | a Health and Welfare | |
700 | 1 | a Kastrup, Jensu Department of Cardiology, Rigshospitalet University of Copenhagen, 2100 Copenhagen, Denmark.4 aut |
700 | 1 | a Sajadieh, Ahmadu Department of Cardiology, Copenhagen University Hospital of Bispebjerg and Frederiksberg, 2000 Frederiksberg, Denmark.4 aut |
700 | 1 | a Jensen, Gorm Bojeu Department of Cardiology, Hvidovre Hospital University of Copenhagen, 2650 Hvidovre, Denmark.4 aut |
700 | 1 | a Kjøller, Eriku Department of Cardiology S, Herlev Hospital University of Copenhagen, Herlev, Denmark; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark,Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.4 aut |
700 | 1 | a Kolmos, Hans Jørnu Department of Clinical Microbiology, Odense University Hospital, 5000 Odense, Denmark.4 aut |
700 | 1 | a Wuopio, Jonasu Department of Medicine, Mora County Hospital, 79251 Mora, Sweden.4 aut |
700 | 1 | a Nowak, Christophu Karolinska Institutet4 aut |
700 | 1 | a Larsson, Andersu Karolinska Institutet,Uppsala universitet,Klinisk kemi4 aut0 (Swepub:uu)andlarss |
700 | 1 | a Jakobsen, Janus Christianu Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Cardiology, Holbæk Hospital, Holbæk, Denmark,Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.4 aut |
700 | 1 | a Winkel, Peru Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.4 aut |
700 | 1 | a Gluud, Christianu Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.4 aut |
700 | 1 | a Iversen, Kasper K.u Department of Cardiology S, Herlev Hospital University of Copenhagen, 2730 Herlev, Denmark.4 aut |
700 | 1 | a Ärnlöv, Johan,d 1970-u Karolinska Institutet,Högskolan Dalarna,Medicinsk vetenskap,Division for Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 14183 Huddinge, Sweden.4 aut0 (Swepub:du)jan |
700 | 1 | a Carlsson, Axel C.u Division for Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 14183 Huddinge, Sweden.4 aut |
710 | 2 | a Örebro universitetb Institutionen för medicinska vetenskaper4 org |
773 | 0 | t Journal of Clinical Medicined : MDPIg 9:1q 9:1x 2077-0383 |
856 | 4 | u https://doi.org/10.3390/jcm9010265y Fulltext |
856 | 4 | u https://www.mdpi.com/2077-0383/9/1/265/pdf |
856 | 4 | u https://du.diva-portal.org/smash/get/diva2:1388967/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1390634/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-80677 |
856 | 4 8 | u https://doi.org/10.3390/jcm9010265 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:du-31734 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-403679 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:143056686 |
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