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Sökning: onr:"swepub:oai:DiVA.org:oru-81567" > Vagotomy and subseq...

  • Liu, BojingDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (författare)

Vagotomy and subsequent risk of inflammatory bowel disease : a nationwide register-based matched cohort study

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-04-22
  • John Wiley & Sons,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-81567
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-81567URI
  • https://doi.org/10.1111/apt.15715DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-170544URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143556756URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Umeå County Council (ALF grant)Mag-tarmfonden  Jane and Dan Olsson foundation  Mjölkdroppen foundation  Bengt Ihre research fellowship in gastroenterology  Swedish Medical Society (fund for research in gastroenterology )  Swedish Medical Society (Bengt Ihre foundation) 
  • Background: The vagus nerve provides essential parasympathetic innervation to the gastrointestinal system and is known to have anti-inflammatory properties.Aims: To explore the relationship between vagotomy and the risk of inflammatory bowel disease (IBD) and its major categories: Crohn's disease (CD) and ulcerative colitis (UC).Methods: A matched cohort comprising 15 637 patients undergoing vagotomy was identified through the Swedish Patient Register from 1964 to 2010. Each vagotomised patient was matched for birth year and gender with 40 nonvagotomised individuals on the date of vagotomy. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for IBD using flexible parametric models adjusted for matching variables, year of vagotomy, birth country, chronic obstructive pulmonary disease and comorbidity index.Results: We observed 119 (0.8%) patients with vagotomy developed IBD compared to 3377 (0.5%) IBD cases in nonvagotomised individuals. The crude incidence of IBD (per 1000 person-years) was 0.38 for vagotomised patients and 0.25 for nonvagotomised individuals. We observed a time-dependent elevated risk of IBD associated with vagotomy, for instance, the HR (95% CI) was 1.80 (1.40-2.31) at year 5 and 1.49 (1.14-1.96) at year 10 post-vagotomy. The association appeared to be stronger for truncal than selective vagotomy and limited to CD (HR was 3.63 [1.94-6.80] for truncal and 2.06 [1.49-2.84] for selective vagotomy) but not UC (1.36 [0.71-2.62] for truncal and 1.25 [0.95-1.63] for selective vagotomy).Conclusions: We found a positive association between vagotomy and later IBD, particularly for CD. The finding indirectly underlines the beneficial role of the vagal tone in IBD.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wanders, AlkwinUmeå universitet,Patologi(Swepub:umu)alwa0025 (författare)
  • Wirdefeldt, KarinKarolinska Institutet (författare)
  • Sjölander, ArvidKarolinska Institutet (författare)
  • Sachs, Michael C.Department of Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
  • Eberhardson, MichaelKarolinska Institutet (författare)
  • Ye, WeiminKarolinska Institutet (författare)
  • Ekbom, AndersKarolinska Institutet (författare)
  • Olén, OlaKarolinska Institutet (författare)
  • Ludvigsson, Jonas F.,1969-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden(Swepub:oru)jsln (författare)
  • Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenPatologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Alimentary Pharmacology and Therapeutics: John Wiley & Sons51:11, s. 1022-10300269-28131365-2036

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