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Anti-inflammatory P...
Anti-inflammatory Properties of Doxycycline and Minocycline in Experimental Models : An in Vivo and in Vitro Comparative Study
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- Leite, Liz M. (författare)
- Faculty of Medicine of Juazeiro de Norte, Juazeiro do Norte, Brazil
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- Carvalho, Antônio Germano G. (författare)
- Faculty of Medicine of Juazeiro de Norte, Juazeiro do Norte, Brazil
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- Tavares Ferreira, Pollyanna L. F. (författare)
- Faculty of Medicine of Juazeiro de Norte, Juazeiro do Norte, Brazil
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- Xavier Pessoa, Igor (författare)
- Faculty of Medicine of Juazeiro de Norte, Juazeiro do Norte, Brazil
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- Gonçalves, Danilo O. (författare)
- Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil
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- de Araújo Lopes, Amanda (författare)
- Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil
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- dos Santos Góes, Jean Guilherme (författare)
- Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil
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- Castro Alves, Victor Costa, 1986- (författare)
- Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil
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- Leal, Luzia Kalyne A. M. (författare)
- Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil
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- Brito, Gerly Anne (författare)
- Faculty of Medicine of Juazeiro de Norte, Juazeiro do Norte, Brazil; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil
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- Viana, Glauce S. B. (författare)
- Faculty of Medicine of Juazeiro de Norte, Juazeiro do Norte, Brazil; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil
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(creator_code:org_t)
- 2011-02-25
- 2011
- Engelska.
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Ingår i: InflammoPharmacology. - : Springer. - 0925-4692 .- 1568-5608. ; 19:2, s. 99-110
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Aims and methods: Minocycline (Mino) and doxycycline (Dox) are second generation tetracyclines known to present several other effects, which are independent from their antimicrobial activities. We studied in a comparative way the anti-inflammatory effects of Mino and Dox, on acute models of peripheral inflammation in rodents (formalin test and peritonitis in mice, and carrageenan-induced paw oedema in rats). Immunohistochemical assays for TNF-alpha and iNOS in rat paws of carrageenan-induced oedema were also carried out as well as in vitro assays for myeloperoxidase (MPO) and lactate dehydrogenase (LDH). Furthermore, antioxidant activities were evaluated by the DPPH assay. Results: In the formalin test although Mino and Dox (1, 5, 10 and 25 mg/kg, i.p.) inhibited the first phase, they acted predominantly on the second phase of the test, where inhibition of the licking time close to 80% were observed. Mino and Dox were very efficacious in reducing the carrageenan-induced paw oedema in rats (10, 25 and 50 mg/kg, i.p.) and carrageenan-induced leucocyte migration (1 and 5 mg/kg, i.p.) to mice peritoneal cavities. Besides, they also significantly inhibited MPO and LDH releases at doses ranging from 0.001 to 1 μg/ml. Thus, in general, the anti-inflammatory activity of Dox was higher as compared to that of Mino, although the radical scavenging activity of Mino was of a magnitude 10 times higher. Conclusions: Our data indicate that anti-inflammatory and antioxidant effects, involve the inhibition of iNOS and TNF-alpha, among other properties, and these encourage clinical studies of these compounds for new therapeutic applications, especially those were inflammation plays a role.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Minocycline
- Doxycycline
- Inflammation
- Cytokines
- Antioxidant effect
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Leite, Liz M.
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Carvalho, Antôni ...
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Tavares Ferreira ...
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Xavier Pessoa, I ...
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Gonçalves, Danil ...
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de Araújo Lopes, ...
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dos Santos Góes, ...
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Castro Alves, Vi ...
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Leal, Luzia Kaly ...
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Brito, Gerly Ann ...
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Viana, Glauce S. ...
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