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Orally administered...
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Salmenkari, H.Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland
(författare)
Orally administered angiotensin-converting enzyme-inhibitors captopril and isoleucine-proline-proline have distinct effects on local renin-angiotensin system and corticosterone synthesis in dextran sulfate sodium-induced colitis in mice
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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Polish Physiological Society,2017
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-83106
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-83106URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The effects of angiotensin-converting enzyme (ACE) inhibition by an antihypertensive drug, captopril, and milk casein-derived ACE-inhibiting bioactive tripeptide isoleucine-proline-proline (Ile-Pro-Pro), on local renin-angiotensin system (RAS) and glucocorticoid production in the intestine were studied in the dextran sodium sulfate induced colitis in mice. Mice received water or 3% dextran sodium sulfate with or without either 15.7 mg/l captopril or 833 mg/l Ile-Pro-Pro for 7 days. Captopril and Ile-Pro-Pro were found to have distinct effects on local renin-angiotensin system and mRNA expression of glucocorticoid synthesis components in colon in vitro. Captopril reduced intestinal mRNA expression of angiotensin-converting enzyme, angiotensinogen and Cyp11b1, whereas Ile-Pro-Pro reduced angiotensin-converting enzyme protein shedding from colon. Neither captopril nor Ile-Pro-Pro changed the expression of glucocorticoid-synthesis driving transcription factor Lrh-1 expression or intestinal glucocorticoid production. Contrary to previous studies, captopril did not alleviate DSS-induced colitis. Furthermore, Ile-Pro-Pro was mildly pro-inflammatory as exhibited by increased pro-inflammatory cytokine interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) levels in colon. The nutritional component Ile-Pro-Pro had different effect on intestinal RAS and glucocorticoid (GC) synthesis pathway than ACE inhibitor captopril, which suggests that the bioactivity of Ile-Pro-Pro is not limited to inhibition of ACE.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Holappa, M.Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland
(författare)
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Forsgård, Richard A.,1987-Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland(Swepub:oru)rfd
(författare)
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Korpela, R.Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland
(författare)
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Vapaatalo, H.Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland
(författare)
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Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Physiology and Pharmacology: Polish Physiological Society68:3, s. 355-3620867-59101899-1505
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