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Urinary concentrati...
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Díaz Santana, Mary V.Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA
(författare)
Urinary concentrations of phthalate biomarkers and weight change among postmenopausal women : a prospective cohort study
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-03-12
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BioMed Central (BMC),2019
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LIBRIS-ID:oai:DiVA.org:oru-83800
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-83800URI
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https://doi.org/10.1186/s12940-019-0458-6DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agency:National Institute of Environmental Health Sciences, Grant Number: R01ES024731, R01ES024731S1National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services, Grant Number: HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, HHSN268201600004C
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BACKGROUND: Some phthalates are endocrine disrupting chemicals used as plasticizers in consumer products, and have been associated with obesity in cross-sectional studies, yet prospective evaluations of weight change are lacking. Our objective was to evaluate associations between phthalate biomarker concentrations and weight and weight change among postmenopausal women.METHODS: We performed cross-sectional (N = 997) and longitudinal analyses (N = 660) among postmenopausal Women's Health Initiative participants. We measured 13 phthalate metabolites and creatinine in spot urine samples provided at baseline. Participants' weight and height measured at in-person clinic visits at baseline, year 3, and year 6 were used to calculate body mass index (BMI). We fit multivariable multinomial logistic regression models to explore cross-sectional associations between each phthalate biomarker and baseline BMI category. We evaluated longitudinal associations between each biomarker and weight change using mixed effects linear regression models.RESULTS: In cross-sectional analyses, urinary concentrations of some biomarkers were positively associated with obesity prevalence (e.g. sum of di (2-ethylhexyl) phthalate metabolites [ΣDEHP] 4th vs 1st quartile OR = 3.29, 95% CI 1.80-6.03 [p trend< 0.001] vs normal). In longitudinal analyses, positive trends with weight gain between baseline and year 3 were observed for mono-(2-ethyl-5-oxohexyl) phthalate, monoethyl phthalate (MEP), mono-hydroxybutyl phthalate, and mono-hydroxyisobutyl phthalate (e.g. + 2.32 kg [95% CI 0.93-3.72] for 4th vs 1st quartile of MEP; p trend < 0.001). No statistically significant associations were observed between biomarkers and weight gain over 6 years.CONCLUSIONS: Certain phthalates may contribute to short-term weight gain among postmenopausal women.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hankinson, Susan E.Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA
(författare)
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Bigelow, CarolDepartment of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA
(författare)
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Sturgeon, Susan R.Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA
(författare)
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Zoeller, R. Thomas,1952-Biology Department, University of Massachusetts, Amherst, USA(Swepub:oru)tzr
(författare)
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Tinker, LesleyCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, USA
(författare)
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Manson, Jo Ann E.Department of Medicine, Harvard Medical School, Boston, USA; Harvard T.H. Chan School of Public Health, Boston, USA
(författare)
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Calafat, Antonia M.Division of Laboratory Sciences, National Center for Environmental Health, Atlanta, USA
(författare)
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Meliker, Jaymie R.Department of Family Population and Preventive Medicine, Stony Brook University, Stony Brook, USA
(författare)
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Reeves, Katherine W.Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USA
(författare)
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Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, USABiology Department, University of Massachusetts, Amherst, USA
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Environmental Health: BioMed Central (BMC)18:11476-069X
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Díaz Santana, Ma ...
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Hankinson, Susan ...
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Bigelow, Carol
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Sturgeon, Susan ...
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Zoeller, R. Thom ...
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Tinker, Lesley
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Manson, Jo Ann E ...
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Calafat, Antonia ...
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Meliker, Jaymie ...
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Reeves, Katherin ...
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