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Maternal serum perf...
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Lebeaux, Rebecca MDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon NH, USA
(författare)
Maternal serum perfluoroalkyl substance mixtures and thyroid hormone concentrations in maternal and cord sera : The HOME Study
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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Elsevier,2020
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-83810
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-83810URI
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https://doi.org/10.1016/j.envres.2020.109395DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies:United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS) P01 ES11261R01 ES014575R01 ES020349R01 ES025214R01 ES024381P01 ES022832-02United States Environmental Protection Agency RD-83544201United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) P20 GM104416United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) 2T32AI007519-21United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) R25 CA134286
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BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are ubiquitous. Previous studies have found associations between PFAS and thyroid hormones in maternal and cord sera, but the results are inconsistent. To further address this research question, we used mixture modeling to assess the associations with individual PFAS, interactions among PFAS chemicals, and the overall mixture.METHODS: We collected data through the Health Outcomes and Measures of the Environment (HOME) Study, a prospective cohort study that between 2003 and 2006 enrolled 468 pregnant women and their children in the greater Cincinnati, Ohio region. We assessed the associations of maternal serum PFAS concentrations measured during pregnancy with maternal (n = 185) and cord (n = 256) sera thyroid stimulating hormone (TSH), total thyroxine (TT4), total triiodothyronine (TT3), free thyroxine (FT4), and free triiodothyronine (FT3) using two mixture modeling approaches (Bayesian kernel machine regression (BKMR) and quantile g-computation) and multivariable linear regression. Additional models considered thyroid autoantibodies, other non-PFAS chemicals, and iodine deficiency as potential confounders or effect measure modifiers.RESULTS: PFAS, considered individually or as mixtures, were generally not associated with any thyroid hormones. A doubling of perfluorooctanesulfonic acid (PFOS) had a positive association with cord serum TSH in BKMR models but the 95% Credible Interval included the null (β = 0.09; 95% CrI: -0.08, 0.27). Using BKMR and multivariable models, we found that among children born to mothers with higher thyroid peroxidase antibody (TPOAb), perfluorooctanoic acid (PFOA), PFOS, and perfluorohexanesulfonic acid (PFHxS) were associated with decreased cord FT4 suggesting modification by maternal TPOAb status.CONCLUSIONS: These findings suggest that maternal serum PFAS concentrations measured in the second trimester of pregnancy are not strongly associated with thyroid hormones in maternal and cord sera. Further analyses using robust mixture models in other cohorts are required to corroborate these findings.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Doherty, Brett TDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon NH, USA
(författare)
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Gallagher, Lisa GIndependent Researcher, Walpole MA, USA
(författare)
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Zoeller, R. Thomas,1952-Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Biology, University of Massachusetts, Amherst MA, USA(Swepub:oru)tzr
(författare)
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Hoofnagle, Andrew NDepartment of Laboratory Medicine, University of Washington, Seattle WA, USA
(författare)
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Calafat, Antonia MDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta GA, USA
(författare)
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Karagas, Margaret RDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon NH, USA
(författare)
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Yolton, KimberlyDivision of Generaland Community Pediatrics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati OH, USA
(författare)
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Chen, AiminDivision of Epidemiology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati OH, USA
(författare)
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Lanphear, Bruce PChild and Family Research Institute, BC Children's and Women's Hospital and Faculty of Health Sciences, Simon Fraser University, Vancouver British Columbia, Canada
(författare)
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Braun, Joseph MDepartment of Epidemiology, Brown University School of Public Health, Providence RI, USA
(författare)
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Romano, Megan EDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon NH, USA
(författare)
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Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon NH, USAIndependent Researcher, Walpole MA, USA
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Environmental Research: Elsevier1850013-93511096-0953
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Lebeaux, Rebecca ...
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Doherty, Brett T
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Zoeller, R. Thom ...
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Hoofnagle, Andre ...
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Calafat, Antonia ...
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Karagas, Margare ...
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Yolton, Kimberly
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Chen, Aimin
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Lanphear, Bruce ...
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Braun, Joseph M
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Romano, Megan E
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