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Sökning: onr:"swepub:oai:DiVA.org:oru-84459" > Prenatal exposure t...

  • McGlinchey, Aidan J,1984-Örebro universitet,Institutionen för medicinska vetenskaper (författare)

Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • Elsevier,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-84459
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84459URI
  • https://doi.org/10.1016/j.envint.2020.105935DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)1DP3DK094338-01Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research 250114Academy of Finland postdoctoral grant 323171Medical Research Funds, Tampere University Hospital Juvenile Diabetes Research Foundation 2-SRA-2016-341-S-B 2-SRA-2016-289-S-BMedical Research Funds, Helsinki University Hospital 
  • In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers of T1D risk in children. In a mother-infant cohort (264 dyads), high PFAS exposure during pregnancy associated with decreased cord serum phospholipids and progression to T1D-associated islet autoantibodies in the offspring. This PFAS-lipid association appears exacerbated by increased human leukocyte antigen-conferred risk of T1D in infants. Exposure to a single PFAS compound or a mixture of organic pollutants in non-obese diabetic mice resulted in a lipid profile characterized by a similar decrease in phospholipids, a marked increase of lithocholic acid, and accelerated insulitis. Our findings suggest that PFAS exposure during pregnancy contributes to risk and pathogenesis of T1D in offspring.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Sinioja, Tim,1983-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)tmsa (författare)
  • Lamichhane, SantoshTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (författare)
  • Sen, ParthoTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (författare)
  • Bodin, JohannaDivision of Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway (författare)
  • Siljander, HeliPediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland (författare)
  • Dickens, Alex M.Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (författare)
  • Geng, DaweiSchool of Science and Technology, Örebro University, Örebro, Sweden (författare)
  • Carlsson, CeciliaSchool of Science and Technology, Örebro University, Örebro, Sweden (författare)
  • Duberg, Daniel,1985-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)ddg (författare)
  • Ilonen, JormaImmunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland; Department of Clinical Microbiology, Turku University Hospital, Turku, Finland (författare)
  • Virtanen, Suvi M.Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; Tampere University Hospital, Research, Development and Innovation Center, Tampere, Finland; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland (författare)
  • Dirven, HubertDivision of Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway (författare)
  • Berntsen, Hanne FriisNorwegian University of Life Sciences, Oslo, Norway; National Institute of Occupational Health, Oslo, Norway (författare)
  • Zimmer, KarinTampere University Hospital, Research, Development and Innovation Center, Tampere, Finland (författare)
  • Nygaard, Unni C.Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway (författare)
  • Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland(Swepub:oru)moc (författare)
  • Knip, MikaelPediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; Tampere University Hospital, Research, Development and Innovation Center, Tampere, Finland; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland (författare)
  • Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)tihn (författare)
  • Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Environment International: Elsevier1430160-41201873-6750

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