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Prevalence of Mycop...
Prevalence of Mycoplasma genitalium and antibiotic resistance-associated mutations in an Icelandic STI population, and comparison of the S-DiaMGTV and Aptima Mycoplasma genitalium assays for diagnosis
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- Hilmarsdóttir, Ingibjörg (författare)
- Department of Microbiology, Landspítali-The University Hospital of Iceland, Reykjavík, Iceland ; Faculty of Medicine, University of Iceland, Reykjavík, Iceland
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- Arnardóttir, Eva Mjöll (författare)
- Department of Microbiology, Landspítali-The University Hospital of Iceland, Reykjavík, Iceland; Faculty of Medicine, University of Iceland, Reykjavík, Iceland
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- Jóhannesdóttir, Elísabet Reykdal (författare)
- Department of Sexually Transmitted Diseases, Landspítali-The University Hospital of Iceland, Reykjavík, Iceland
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- Valsdóttir, Freyja (författare)
- Department of Microbiology, Landspítali-The University Hospital of Iceland, Reykjavík, Iceland
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- Golparian, Daniel, 1984- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Department of Laboratory Medicine
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- Hadad, Ronza, 1984- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Department of Laboratory Medicine
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- Vigfússon, Hannes Bjarki (författare)
- Department of Microbiology, Landspítali-The University Hospital of Iceland, Reykjavík, Iceland
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- Unemo, Magnus, 1970- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Department of Laboratory Medicine
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(creator_code:org_t)
- American Society for Microbiology, 2020
- 2020
- Engelska.
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Ingår i: Journal of Clinical Microbiology. - : American Society for Microbiology. - 0095-1137 .- 1098-660X. ; 58:9
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives: Mycoplasma genitalium (MG) is prevalent among attendees in sexually transmitted infections (STI) clinics and therapy is hampered by rapidly rising levels of resistance to azithromycin and moxifloxacin. In this study we evaluated, for the first time in Iceland, the prevalence of MG and azithromycin and moxifloxacin resistance-associated mutations, and assessed the diagnostic performance of the CE/IVD-marked S-DiaMGTV (Diagenode Diagnostics) versus the US FDA/CE/IVD-approved Aptima MG (AMG; Hologic) for MG detection.Methods: From October 2018 to January 2019, urine and vaginal swabs were provided by male and female attendees at Iceland's only STI clinic. Specimens were tested with S-DiaMGTV and AMG, and resistance-associated mutations were determined by 23S rRNA gene and parC sequencing. Demographic and clinical data were collected from patient records.Results: MG prevalence was 9.3% overall; 7.7% (38/491) among male and 10.9% (53/487) among female participants. Azithromycin and moxifloxacin resistance-associated mutations were found in 57.0% (45/79) and 0.0% (0/80) of evaluable specimens, respectively. Sensitivity was 72.5% and 100%, and specificity was 99.9% and 100% for S-DiaMGTV and AMG, respectively. No association was found between MG and symptoms of urethritis in men.Conclusions: Prevalence rates for MG and azithromycin resistance-associated genes in Iceland are among the highest reported in Europe. The significantly higher sensitivity of AMG over that of S-DiaMGTV can have important clinical implications. More information is urgently needed to clarify the significance of false-negative results obtained with S-DiaMGTV and other similarly performing, widely used real-time PCR methods for diagnosis and management of this sexually transmitted infection.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- 23S rRNA: Iceland: antimicrobial resistance: azithromycin: moxifloxacin parC: urethritis
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Hilmarsdóttir, I ...
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Arnardóttir, Eva ...
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Jóhannesdóttir, ...
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Valsdóttir, Frey ...
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Golparian, Danie ...
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Hadad, Ronza, 19 ...
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Vigfússon, Hanne ...
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Unemo, Magnus, 1 ...
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- MEDICIN OCH HÄLSOVETENSKAP
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Örebro universitet