Sökning: onr:"swepub:oai:DiVA.org:oru-84776" >
Infections in patie...
Infections in patients with multiple sclerosis : A national cohort study in Sweden
-
- Castelo-Branco, Anna (författare)
- Real-world Insights, IQVIA Nordics, Solna, Sweden
-
- Chiesa, Flaminia (författare)
- Real-world Insights, IQVIA Nordics, Solna, Sweden
-
- Conte, Simona (författare)
- Real-world Insights, IQVIA Nordics, Solna, Sweden
-
visa fler...
-
- Bengtsson, Camilla (författare)
- Real-world Insights, IQVIA Nordics, Solna, Sweden
-
- Lee, Sally (författare)
- Celgene Corporation, 86 Morris Avenue, Summit, United States
-
- Minton, Neil (författare)
- Celgene Corporation, Summit, United States
-
- Niemcryk, Steve (författare)
- Celgene Corporation, Summit, United States
-
- Lindholm, Anders (författare)
- Celgene Corporation, Summit, United States
-
- Rosenlund, Mats (författare)
- Karolinska Institutet
-
- Piehl, Fredrik (författare)
- Karolinska Institutet
-
- Montgomery, Scott, 1961- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Örebro University Hospital, Örebro, Sweden; Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, United Kingdom,Clinical Epidemiology and Biostatistics
-
visa färre...
-
(creator_code:org_t)
- Elsevier, 2020
- 2020
- Engelska.
-
Ingår i: Multiple Sclerosis and Related Disorders. - : Elsevier. - 2211-0348 .- 2211-0356. ; 45
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
http://www.msard-jou...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Multiple sclerosis (MS) patients have an increased risk of infections, but few population-based studies have reported infections occurring in MS in the years immediately after diagnosis.OBJECTIVE: To explore incident infections in MS, stratified by age and sex.METHODS: In a Swedish population-based cohort study 6602 incident MS patients (aged ≥18 years), matched at diagnosis with 61,828 matched MS-free individuals were identified between 1st January 2008 and 31st December 2016, using national registers. Incidence rates (IR) and incidence rate ratios (IRR) with 95% CI were calculated for each outcome.RESULTS: The IRRs were 2.54 (95% CI 2.28-2.83) for first serious infection and 1.61 (1.52-1.71) for first non-serious infection. Compared with MS-free individuals, MS patients had higher IRs for skin, respiratory/throat infections, pneumonia/influenza, bacterial, viral, and fungal infections, with the highest IRR observed for urinary tract/kidney infections (2.44; 2.24-2.66). The cumulative incidence for most of these infections was higher among MS patients than MS-free individuals, both 0 to <5 and 5 to <9 years after index date.CONCLUSION: The burden of infections around the time of MS diagnosis and subsequent infection risk, underscore the need for careful considerations regarding the risk-benefit across different disease-modifying therapies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Cohort study
- Comorbidities
- Health registers
- Incidence
- Infections
- Multiple sclerosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Castelo-Branco, ...
-
Chiesa, Flaminia
-
Conte, Simona
-
Bengtsson, Camil ...
-
Lee, Sally
-
Minton, Neil
-
visa fler...
-
Niemcryk, Steve
-
Lindholm, Anders
-
Rosenlund, Mats
-
Piehl, Fredrik
-
Montgomery, Scot ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Infektionsmedici ...
- Artiklar i publikationen
-
Multiple Scleros ...
- Av lärosätet
-
Örebro universitet
-
Karolinska Institutet