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Anti-HCV prevalence...
Anti-HCV prevalence and risk factor-based screening for hepatitis C in pregnant women and their partners in Sweden
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- Millbourn, Charlotta (författare)
- Karolinska Institutet
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- Lybeck, Charlotte, 1979- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious Diseases
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- Einberg, Afrodite Psaros (författare)
- Karolinska Institutet
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- Nordin, Margareta (författare)
- Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden
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- Lindh, Gudrun (författare)
- Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden
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- Hökeberg, Ingegerd (författare)
- Department of Communicable Disease Prevention and Control, Stockholm County Council, Stockholm, Sweden
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- Fredlund, Hans (författare)
- Department of Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Fischler, Björn (författare)
- Karolinska Institutet
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- Fadl, Helena, 1965- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Obstetrics and Gynecology
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- Duberg, Ann-Sofi, Docent, 1957- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious Diseases
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- Lindahl, Karin (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-07-11
- 2020
- Engelska.
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Ingår i: Infectious Diseases. - : Taylor & Francis. - 2374-4235 .- 2374-4243. ; 52:11, s. 776-785
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: The hepatitis C virus (HCV) prevalence in Sweden is estimated to be <0.5%, but unclear in pregnant women. The dominating route of transmission is drug use (DU), blood transfusions constituted a risk before 1992. The aim was to examine the anti-HCV prevalence and risk factors for HCV among pregnant women and their partners to evaluate screening strategies.Methods: Pregnant women and partners in Örebro County and in southern Stockholm were offered HCV-screening when visiting an antenatal clinic in 2013-2016, and completed a questionnaire concerning the country of birth, knowledge of HCV-status and HCV risk factors.Results: In Örebro 2,827 pregnant women and 707 partners, and in Stockholm 1,281 pregnant women and 320 partners participated. Anti-HCV was positive in 34 (0.7%) (25 pregnant women) and the associated risk factors were DU (n = 27), partner with HCV (n = 24) and not born in Sweden (n = 8). HCV RNA was positive in 23 (0.4%), 4 previously unknown and 10 who had been lost to follow-up. The most effective risk factor-based screening model for pregnant women included DU, blood transfusions, born in high prevalence country, partner with HCV, resulting in 538 (13%) pregnant women tested with 96% sensitivity, 87% specificity.Conclusions: In this study of expecting parents in two Swedish regions, the anti-HCV prevalence was 0.7% and 0.4% were viraemic, of which about 60% were previously unknown or lost to follow-up. Awaiting more studies, including cost-benefit analysis evaluating universal screening, we recommend this improved risk factor-based screening model to identify HCV-infected individuals who need follow-up and therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- HCV
- HCV RNA
- pregnancy
- MTCT
- IDU
- risk factor-based
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Millbourn, Charl ...
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Lybeck, Charlott ...
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Einberg, Afrodit ...
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Nordin, Margaret ...
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Lindh, Gudrun
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Hökeberg, Ingege ...
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Fredlund, Hans
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Fischler, Björn
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Fadl, Helena, 19 ...
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Duberg, Ann-Sofi ...
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Lindahl, Karin
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- Artiklar i publikationen
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Infectious Disea ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet