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Global variability ...
Global variability of the human IgG glycome
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- Štambuk, Jerko (författare)
- Genos Glycoscience Research Laboratory, Zagreb, Croatia
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- Nakić, Natali (författare)
- Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy
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- Vučković, Frano (författare)
- Genos Glycoscience Research Laboratory, Zagreb, Croatia
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- Pučić-Baković, Maja (författare)
- Genos Glycoscience Research Laboratory, Zagreb, Croatia
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- Razdorov, Genadij (författare)
- Genos Glycoscience Research Laboratory, Zagreb, Croatia
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- Trbojević-Akmačić, Irena (författare)
- Genos Glycoscience Research Laboratory, Zagreb, Croatia
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- Novokmet, Mislav (författare)
- Genos Glycoscience Research Laboratory, Zagreb, Croatia
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- Keser, Toma (författare)
- Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
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- Vilaj, Marija (författare)
- Genos Glycoscience Research Laboratory, Zagreb, Croatia
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- Štambuk, Tamara (författare)
- Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
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- Gudelj, Ivan (författare)
- Genos Glycoscience Research Laboratory, Zagreb, Croatia
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- Šimurina, Mirna (författare)
- Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
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- Song, Manshu (författare)
- Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China; School of Medical and Health Sciences, Edith Cowan University, Perth, Australia
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- Wang, Hao (författare)
- Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China; School of Medical and Health Sciences, Edith Cowan University, Perth, Australia
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- Salihović, Marijana Peričić (författare)
- Institute for Anthropological Research, Zagreb, Croatia
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- Campbell, Harry (författare)
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom
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- Rudan, Igor (författare)
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom
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- Kolčić, Ivana (författare)
- School of Medicine, University of Split, Split, Croatia
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- Eller, Leigh Anne (författare)
- Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA
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- McKeigue, Paul (författare)
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom
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- Robb, Merlin L. (författare)
- Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA
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- Halfvarson, Jonas, 1970- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology
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- Kurtoglu, Metin (författare)
- Department of Oncology, Koç University School of Medicine, Istanbul, Turkey
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- Annese, Vito (författare)
- Careggi University Hospital, Florence, Italy
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- Škarić-Jurić, Tatjana (författare)
- Institute for Anthropological Research, Zagreb, Croatia
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- Molokhia, Mariam (författare)
- School of Population Health and Environmental Sciences, King's College London, London, United Kingdom
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- Polašek, Ozren (författare)
- School of Medicine, University of Split, Split, Croatia
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- Hayward, Caroline (författare)
- MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
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- Kibuuka, Hannah (författare)
- Makerere University Walter Reed Project, Kampala, Uganda
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- Thaqi, Kujtim (författare)
- Institute of Clinical Biochemistry, Priština, Kosovo
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- Primorac, Dragan (författare)
- St. Catherine Hospital, Zagreb, Croatia
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- Gieger, Christian (författare)
- Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
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- Nitayaphan, Sorachai (författare)
- Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
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- Spector, Tim (författare)
- Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
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- Wang, Youxin (författare)
- Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China; School of Medical and Health Sciences, Edith Cowan University, Perth, Australia
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- Tillin, Therese (författare)
- Institute of Cardiovascular Science, Faculty of Population Health Sciences, London, United Kingdom
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- Chaturvedi, Nish (författare)
- Institute of Cardiovascular Science, Faculty of Population Health Sciences, London, United Kingdom
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- Wilson, James F. (författare)
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom; MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
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- Schanfield, Moses (författare)
- Department of Forensic Sciences, George Washington University, Washington, USA
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- Filipenko, Maxim (författare)
- Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia
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- Wang, Wei (författare)
- Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China; School of Medical and Health Sciences, Edith Cowan University, Perth, Australia
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- Lauc, Gordan (författare)
- Genos Glycoscience Research Laboratory, Zagreb, Croatia; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
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(creator_code:org_t)
- 2020-08-12
- 2020
- Engelska.
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Ingår i: Aging. - : Impact Journals LLC. - 1945-4589. ; 12:15, s. 15222-15259
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Immunoglobulin G (IgG) is the most abundant serum antibody which structural characteristics and effector functions are modulated through the attachment of various sugar moieties called glycans. Composition of the IgG N-glycome changes with age of an individual and in different diseases. Variability of IgG glycosylation within a population is well studied and is known to be affected by both genetic and environmental factors. However, global inter-population differences in IgG glycosylation have never been properly addressed. Here we present population-specific N-glycosylation patterns of IgG, analyzed in 5 different populations totaling 10,482 IgG glycomes, and of IgG's fragment crystallizable region (Fc), analyzed in 2,579 samples from 27 populations sampled across the world. Country of residence associated with many N-glycan features and the strongest association was with monogalactosylation where it explained 38% of variability. IgG monogalactosylation strongly correlated with the development level of a country, defined by United Nations health and socioeconomic development indicators, and with the expected lifespan. Subjects from developing countries had low levels of IgG galactosylation, characteristic for inflammation and ageing. Our results suggest that citizens of developing countries may be exposed to environmental factors that can cause low-grade chronic inflammation and the apparent increase in biological age.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Fc glycosylation
- aging
- glycans
- immunoglobulin G
- mass spectrometry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Aging
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
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Štambuk, Jerko
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Nakić, Natali
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Vučković, Frano
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Pučić-Baković, M ...
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Razdorov, Genadi ...
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Trbojević-Akmači ...
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visa fler...
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Novokmet, Mislav
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Keser, Toma
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Vilaj, Marija
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Štambuk, Tamara
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Gudelj, Ivan
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Šimurina, Mirna
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Song, Manshu
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Wang, Hao
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Salihović, Marij ...
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Campbell, Harry
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Rudan, Igor
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Kolčić, Ivana
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Eller, Leigh Ann ...
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McKeigue, Paul
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Robb, Merlin L.
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Halfvarson, Jona ...
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Kurtoglu, Metin
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Annese, Vito
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Škarić-Jurić, Ta ...
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Molokhia, Mariam
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Polašek, Ozren
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Hayward, Carolin ...
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Kibuuka, Hannah
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Thaqi, Kujtim
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Primorac, Dragan
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Gieger, Christia ...
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Nitayaphan, Sora ...
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Spector, Tim
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Wang, Youxin
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Tillin, Therese
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Chaturvedi, Nish
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Wilson, James F.
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Schanfield, Mose ...
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Filipenko, Maxim
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Wang, Wei
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Lauc, Gordan
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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Aging
- Av lärosätet
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Örebro universitet