Faecal microbiota signatures of IBD and their relation to diagnosis, disease phenotype, inflammation, treatment escalation and anti-TNF response in a European Multicentre Study (IBD-Character)

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Faecal microbiota signatures of IBD and their relation to diagnosis, disease phenotype, inflammation, treatment escalation and anti-TNF response in a European Multicentre Study (IBD-Character)

Vatn, S. (författare): Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Akershus Univ Hosp, Norway; Univ Oslo, Norway

Carstens, Adam, 1975- (författare): Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Department of Internal Medicine, Ersta Hospital, Stockholm, Sweden,Orebro Univ, Sweden; Ersta Hosp, Sweden

Kristoffersen, A. B. (författare): Genetic Analysis AS, Oslo, Norway,Genet Anal AS, Norway

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Bergemalm, Daniel, 1977- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology,Orebro Univ, Sweden

Olbjorn, C. (författare): Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Univ Oslo, Norway

Moen, A. E. F. (författare): Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Clinical Molecular Biology (EpiGen), Division of Medicine, Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway

Tannaes, T. M. (författare): Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Clinical Molecular Biology (EpiGen), Division of Medicine, Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway

Lindstrøm, J. (författare): Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway; Department of Pediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway,Univ Oslo, Norway; Akershus Univ Hosp, Norway

Detlie, T. E. (författare): Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Akershus Univ Hosp, Norway; Univ Oslo, Norway

Olbjørn, C. (författare): Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden

Lindqvist, Carl Mårten, 1979- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology,Orebro Univ, Sweden

Söderholm, Johan D., 1958- (författare): Digestive Diseases Unit, IIS Aragón, Zaragoza, Spain

Gomollón, F. (författare): Gastrointestinal Unit, Centre for Genomics and Molecular Medicine, Division of Medical and Radiological Sciences, University of Edinburgh, Edinburgh, UK,Univ Edinburgh, Scotland

Kalla, R. (författare): Translational Gastroenterology Unit, Medical Sciences/Experimental Medicine Division, University of Oxford, Oxford, UK,Univ Oxford, England

Satsangi, J. (författare): Translational Gastroenterology Unit, Medical Sciences/Experimental Medicine Division, University of Oxford, Oxford, UK,Univ Oxford, England

Vatn, M. H. (författare): Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Univ Oslo, Norway

Jahnsen, J. (författare): Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Akershus Univ Hosp, Norway; Univ Oslo, Norway,Orebro Univ, Sweden

Halfvarson, Jonas, 1970- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology

Ricanek, P. (författare): Department of Gastroenterology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Norway

Casen, C (författare)

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(creator_code:org_t)

2020-08-11
2020
Engelska.
Ingår i: Scandinavian Journal of Gastroenterology. - : Taylor & Francis. - 0036-5521 .- 1502-7708. ; 55:10, s. 1146-1156

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Method: We examined faecal samples, using the GA-map (TM) Dysbiosis Test, to associate gut microbiota composition with Crohn's disease (CD) and ulcerative colitis (UC) and to identify markers for future biomarker identification. We conducted a prospective case-control study (EU-ref. no. 305676) in an inception cohort of 324 individuals (64 CD, 84 UC, 116 symptomatic non-IBD controls and 44 healthy controls) across five European centres and examined 54 predetermined bacterial markers. We categorized patients according to the Montreal Classification and calculated the dysbiosis index (DI). Non-parametric tests were used to compare groups and the Bonferroni correction to adjust for multiple comparisons.Results: The fluorescent signals (FSSs) for Firmicutes and Eubacterium hallii were lower in inflammatory bowel disease (IBD) vs. symptomatic controls (p<.05). FSS for Firmicutes, Lachnospiraceae, Eubacterium hallii and Ruminococcus albus/bromii were lower, whereas the signal fo rBacteroides Fragilis was higher in UC vs. symptomatic controls (p<.05). FSS was higher for Bifidobacterium spp., Eubacterium hallii, Actinobacteria and Firmicutes among patients with ulcerative proctitis, compared to extensive colitis (p<.05). In CD, we observed no association with disease location. The DI correlated with faecal-calprotectin in both CD and in UC (p<.001). In terms of treatment escalation and anti-TNF response, differences were observed for some bacterial markers, but none of these associations were statistically significant.Conclusion: Our data reveal that the GA-map (TM) Dysbiosis Test holds the potential to characterize the faecal microbiota composition and to assess the degree of dysbiosis in new-onset IBD. On the other hand, our results cannot demonstrate any proven diagnostic or predictive value of this method to support clinical decision making.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

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Faecal microbiota signatures of IBD and their relation to diagnosis, disease phenotype, inflammation, treatment escalation and anti-TNF response in a European Multicentre Study (IBD-Character)

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