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Peritoneal dialysis...
Peritoneal dialysis fluid-induced angiogenesis in rat mesentery is increased by lactate in the presence or absence of glucose
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- Albrektsson, Ann, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Bazargani, Farhan, 1969- (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Wieslander, A. (författare)
- Gambro AB, Lund, Sweden
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- Braide, Magnus, 1955 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2006
- 2006
- Engelska.
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Ingår i: ASAIO journal (1992). - : Lippincott Williams & Wilkins. - 1058-2916 .- 1538-943X. ; 52:3, s. 276-281
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Angiogenesis may be an important mechanism behind the functional deterioration of the peritoneum leading to ultrafiltration failure in peritoneal dialysis. The present study was designed to compare the angiogenic properties of lactate-, bicarbonate-, and pyruvate-buffered fluids, evaluated separately with and without glucose. Five different fluids (lactate and bicarbonate with and without 2.5% glucose and pyruvate without glucose) were studied for 5 weeks of twice-daily injections in rats. The respective buffers (40 mmol/l) were adjusted to pH 7.2, and sodium, chloride, calcium, and magnesium were present at standard concentrations. The mesenteric window model, based on observation of the translucent peritoneal sections of the small intestine mesentery, was used for immunohistochemical imaging of microvessels (RECA-1 antigen) and macrophages (ED1 and ED2 antigens). All fluids induced angiogenesis as compared with untreated controls. The lactate-buffered fluids induced larger vascularized zones than did their bicarbonate- and pyruvate-buffered counterparts. Angiogenesis was accompanied by a local recruitment of ED1 macrophages from blood. Addition of glucose to the lactate- and bicarbonate-buffered fluids did not seem to alter their pro-angiogenic properties. In conclusion, intraperitoneal exposure to lactate buffer, compared with bicarbonate, stimulates angiogenesis in the presence or absence of glucose.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Antigens
- Fluid mechanics
- Genetic engineering
- Glucose
- Immunology
- Medical imaging
- pH effects
- Fluid-induced angiogenesis
- Peritoneal dialysis
- Ultrafiltration failure
- Blood vessel prostheses
- antigen
- bicarbonate
- buffer
- calcium
- cell antigen
- ed 1 antigen
- ed 2 antigen
- lactic acid
- magnesium
- peritoneal dialysis fluid
- pyruvic acid
- reca 1 antigen
- sodium chloride
- unclassified drug
- dialysis fluid
- lactic acid derivative
- angiogenesis
- animal experiment
- animal model
- animal tissue
- article
- concentration (parameters)
- controlled study
- diagnostic imaging
- imaging system
- immunohistochemistry
- macrophage
- male
- mesentery
- microvasculature
- nonhuman
- pH
- rat
- small intestine
- animal
- comparative study
- drug effect
- fluorescence microscopy
- methodology
- peritoneum macrophage
- Sprague Dawley rat
- time
- vascularization
- Animals
- Bicarbonates
- Buffers
- Dialysis Solutions
- Hydrogen-Ion Concentration
- Lactates
- Macrophages
- Peritoneal
- Microscopy
- Fluorescence
- Neovascularization
- Physiologic
- Rats
- Rats
- Sprague-Dawley
- Time Factors
- Animals
- Bicarbonates
- pharmacology
- Buffers
- Dialysis Solutions
- Glucose
- Hydrogen-Ion Concentration
- Immunohistochemistry
- Lactates
- Macrophages
- Peritoneal
- drug effects
- Male
- Mesentery
- blood supply
- Microscopy
- Fluorescence
- Neovascularization
- Physiologic
- Peritoneal Dialysis
- methods
- Pyruvic Acid
- Rats
- Sprague-Dawley
- Time Factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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