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The P300 event-rela...
The P300 event-related brain potential as a neurobiological endophenotype for substance use disorders : a meta-analytic investigation
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- Euser, Anja S (författare)
- Institute of Psychology, Erasmus University Rotterdam, The Netherlands; Department of Child and Adolescent Psychiatry, Erasmus Medical Center Rotterdam, The Netherlands
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- Arends, Lidia R (författare)
- Institute of Psychology, Erasmus University Rotterdam, The Netherlands; Department of Biostatistics, Erasmus Medical Center Rotterdam, The Netherlands
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- Evans, Brittany E, 1982- (författare)
- Department of Child and Adolescent Psychiatry, Erasmus Medical Center Rotterdam, The Netherlands; Research Institute of Child Development and Education, University of Amsterdam, Amsterdam, The Netherlands
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- Greaves-Lord, Kirstin (författare)
- Department of Child and Adolescent Psychiatry, Erasmus Medical Center Rotterdam, The Netherlands
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- Huizink, Anja C (författare)
- Research Institute of Child Development and Education, University of Amsterdam, Amsterdam, The Netherlands; Behavioral Science Institute, Radboud University, Nijmegen, The Netherlands; Research Institute for Addiction (IVO), Rotterdam, The Netherlands
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- Franken, Ingmar H A (författare)
- Institute of Psychology, Erasmus University Rotterdam, The Netherlands
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(creator_code:org_t)
- Pergamon Press, 2012
- 2012
- Engelska.
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Ingår i: Neuroscience and Biobehavioral Reviews. - : Pergamon Press. - 0149-7634 .- 1873-7528. ; 36:1, s. 572-603
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Endophenotypes are intermediate phenotypes on the putative causal pathway from genotype to phenotype and can aid in discovering the genetic etiology of a disorder. There are currently very few suitable endophenotypes available for substance use disorders (SUD). The amplitude of the P300 event-related brain potential is a possible candidate. The present study determined whether the P300 amplitude fulfils two fundamental criteria for an endophenotype: (1) an association with the disorder (disease marker), and (2) presence in unaffected biological relatives of those who have the disorder (vulnerability marker). For this purpose, two separate meta-analyses were performed. Meta-analysis 1 investigated the P300 amplitude in relation to SUD in 39 studies and Meta-analysis 2 investigated P300 amplitude in relation to a family history (FH+) of SUD in 35 studies. The findings indicate that a reduced P300 amplitude is significantly associated with SUD (d=0.51) and, though to a lesser extent, with a FH+ of SUD (d=0.28). As a disease maker, the association between reduced P300 amplitude and SUD is significantly larger for participants that were exclusively recruited from treatment facilities (d=0.67) than by other methods (i.e., community samples and family studies; d=0.45 and 0.32, respectively), and larger for abstinent SUD patients (d=0.71) than for current substance users (d=0.37). Furthermore, in contrast to FH+ males, a P300 amplitude reduction seems not to be present in FH+ females (d=-0.07). Taken together, these results suggest that P300 amplitude reduction can be both a useful disease and vulnerability marker and is a promising neurobiological endophenotype for SUD, though only in males. Implications and future directions are discussed.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology -- Psychology (hsv//eng)
Nyckelord
- P300
- Event-related potentials
- Endophenotype
- Substance use disorders
- Family history
- High-risk
- Oddball paradigm
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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