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Gonorrhoea treatmen...
Gonorrhoea treatment combined with population-level general cephalosporin and quinolone consumption may select for Neisseria gonorrhoeae antimicrobial resistance at the levels of NG-MAST genogroup : an ecological study in Europe
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- Kenyon, Chris (författare)
- HIV/STI Unit, Institute of Tropical Medicine, Antwerp, Belgium; Division of Infectious Diseases and HIV Medicine, University of Cape Town, Anzio Road, Observatory, South Africa
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- Laumen, Jolein (författare)
- HIV/STI Unit, Institute of Tropical Medicine, Antwerp, Belgium
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- Van Dijck, Christophe (författare)
- HIV/STI Unit, Institute of Tropical Medicine, Antwerp, Belgium
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- De Baetselier, Irith (författare)
- HIV/STI Unit, Institute of Tropical Medicine, Antwerp, Belgium
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- Abdelatti, Saïd (författare)
- HIV/STI Unit, Institute of Tropical Medicine, Antwerp, Belgium
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- Manoharan-Basil, Sheeba S. (författare)
- HIV/STI Unit, Institute of Tropical Medicine, Antwerp, Belgium
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- Unemo, Magnus, 1970- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Department of Laboratory Medicin
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(creator_code:org_t)
- Elsevier, 2020
- 2020
- Engelska.
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Ingår i: Journal of Global Antimicrobial Resistance. - : Elsevier. - 2213-7165 .- 2213-7173. ; 23, s. 377-384
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: The prevalence of Neisseria gonorrhoeae NG-MAST genogroup G1407, associated with decreased susceptibility to extended-spectrum cephalosporins and fluoroquinolone resistance, has declined in Europe and it switched from circulating predominantly in men who have sex with men (MSM) in 2009-10 to heterosexuals in 2013. We hypothesized that changes to gonorrhoea treatment guidelines combined with differences in country-level consumption of cephalosporins and quinolones contributed to this shift.METHODS: Linear regression was used to evaluate associations between changes in prevalence of G1407 from 2009-10 to 2013 and country-level consumption of quinolones and cephalosporins in 2011/12 in 20 European countries.RESULTS: Whilst the prevalence of G1407 declined from 2009-10 to 2013 in the EU/EEA, its absolute prevalence increased by 10% or more in 3 countries. The national prevalence of G1407 in 2013 was positively associated with population-level general cephalosporin and quinolone consumption in the preceding two years. The association between the prevalence of G1407 and proportion of the national sample derived from MSM was non-significant in 2009-10 and negative in 2013.CONCLUSIONS: Our results are broadly compatible with the hypothesis that changes in gonorrhoea therapy to the more efficacious ceftriaxone (plus azithromycin) from 2010-11 and onwards resulted in a reduced prevalence of the resistance associated-G1407 overall but in MSM in particular. High population-level consumption of quinolones and cephalosporins in certain countries then contributed to the selection of G1407 predominantly in heterosexuals in these countries.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Neisseria gonorrhoeae
- antimicrobial consumption
- antimicrobial resistance
- ecological
- gonorrhoea
- stewardship
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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