Systems biology approaches to study lipidomes in health and disease

Alves, Marina AmaralTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (författare)

Lipids have many important biological roles, such as energy storage sources, structural components of plasma membranes and as intermediates in metabolic and signaling pathways. Lipid metabolism is under tight homeostatic control, exhibiting spatial and dynamic complexity at multiple levels. Consequently, lipid-related disturbances play important roles in the pathogenesis of most of the common diseases. Lipidomics, defined as the study of lipidomes in biological systems, has emerged as a rapidly-growing field. Due to the chemical and functional diversity of lipids, the application of a systems biology approach is essential if one is to address lipid functionality at different physiological levels. In parallel with analytical advances to measure lipids in biological matrices, the field of computational lipidomics has been rapidly advancing, enabling modeling of lipidomes in their pathway, spatial and dynamic contexts. This review focuses on recent progress in systems biology approaches to study lipids in health and disease, with specific emphasis on methodological advances and biomedical applications.

Lamichhane, SantoshTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (författare)
Dickens, AlexTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (författare)
McGlinchey, Aidan J,1984-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)anmy (författare)
Ribeiro, Henrique C.Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland (författare)
Sen, Partho,1983-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland(Swepub:oru)posn (författare)
Wei, FangOil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan, P. R. China (författare)
Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)tihn (författare)
Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland(Swepub:oru)moc (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, FinlandInstitutionen för medicinska vetenskaper (creator_code:org_t)

Ingår i:Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids: Elsevier1866:21388-19811879-2618

Av författaren/redakt...: Alves, Marina Am ...; Lamichhane, Sant ...; Dickens, Alex; McGlinchey, Aida ...; Ribeiro, Henriqu ...; Sen, Partho, 198 ...; visa fler...; Wei, Fang; Hyötyläinen, Tuu ...; Oresic, Matej, 1 ...; visa färre...

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