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The associations be...
The associations between p,p'-DDE levels and plasma levels of lipoproteins and their subclasses in an elderly population determined by analysis of lipoprotein content
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- Jugan, Juliann (författare)
- Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA, USA,Univ Calif Davis, Dept Environm Toxicol, One Shields Ave, Davis, CA 95616 USA.
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- Lind, P. Monica, 1957- (författare)
- Uppsala universitet,Arbets- och miljömedicin
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- Salihovic, Samira, Associate Senior Lecturer, 1985- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre; MTM Research Centre,Örebro Univ, Sch Med Sci, Inflammatory Response & Infect Susceptibil Ctr, Örebro, Sweden.;Örebro Univ, Sch Sci & Technol, MTM Res Ctr, Örebro, Sweden.
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- Stubleski, Jordan (författare)
- Wellington Laboratories Inc., Guelph, ON, Canada,Wellington Labs Inc, Guelph, ON, Canada.
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- Kärrman, Anna, 1975- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre,Örebro Univ, Sch Sci & Technol, MTM Res Ctr, Örebro, Sweden.
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- Lind, Lars (författare)
- Uppsala universitet,Klinisk epidemiologi,Cardiovascukar Epidemiology
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- La Merrill, Michele A. (författare)
- Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA, USA,Univ Calif Davis, Dept Environm Toxicol, One Shields Ave, Davis, CA 95616 USA.
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Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA, USA Univ Calif Davis, Dept Environm Toxicol, One Shields Ave, Davis, CA 95616 USA (creator_code:org_t)
- 2020-12-07
- 2020
- Engelska.
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Ingår i: Lipids in Health and Disease. - : BioMed Central (BMC). - 1476-511X. ; 19:1
- Relaterad länk:
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https://doi.org/10.1...
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https://lipidworld.b...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Lipoproteins at aberrant levels are known to play a role in cardiovascular disease. The metabolite of the insecticide dichlorodiphenyltrichloroethane (DDT), p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), physically associates with lipids and accumulates in adipose tissue. Little is known about which lipoproteins associate with p,p'-DDE. An association between p,p'-DDE exposure and altered levels of circulating lipids was assessed in a large human cohort using a detailed analysis of lipoprotein content.METHODS: Plasma samples were collected from the subset of 75-year old Swedes in the Prospective Investigation of the Vasculature of Uppsala Seniors (PIVUS) cohort who were not prescribed lipid lowering medication (n = 571). p,p'-DDE concentrations in plasma were measured using high-throughput solid phase extraction and gas chromatography-high resolution mass spectrometry. Analysis of plasma lipoprotein content was performed with nuclear magnetic resonance spectroscopy.RESULTS: Detectable levels of p,p'-DDE were found in the plasma samples of all subjects. Elevated p,p'-DDE levels were associated with increased concentrations of lipoproteins of all diameters, with the exception of high density lipoprotein (HDL) of diameters between 14.3 nm-10.9 nm. Of the lipoprotein constituents, triglycerides were most uniformly associated with elevated p,p'-DDE across lipoproteins. p,p'-DDE was furthermore associated with apolipoprotein B, but not apolipoprotein A1.CONCLUSIONS: The positive associations observed between each lipoprotein class and elevated p,p'-DDE support previous data suggesting that p,p'-DDE interacts with lipoproteins within plasma. It is speculated that both physio-chemical and biological mechanisms may explain why p,p'-DDE does not uniformly associate with lipids across lipoproteins.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Cardiovascular disease
- Cholesterol
- Dichlorodiphenyldichloroethylene
- Lipoprotein
- Persistent organic pollutants
- Phospholipids
- Triglycerides
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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