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A population-based ...
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Sujan, Ayesha C.Department of Psychological & Brain Sciences, Indiana University-Bloomington, Bloomington, IN, USA
(författare)
A population-based study of concurrent prescriptions of opioid analgesic and selective serotonin reuptake inhibitor medications during pregnancy and risk for adverse birth outcomes
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2020-12-22
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Blackwell Science Ltd.2021
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-88425
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-88425URI
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https://doi.org/10.1111/ppe.12721DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:145491567URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Funding Agencies:National Science Foundation (NSF)1342962United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Drug Abuse (NIDA) R00DA040727 R01DA048042Swedish Initiative for Research on Microdata in the Social and Medical Sciences 340-20135867
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BACKGROUND: Pregnant women with painful conditions often have mental health problems, including depression and anxiety. Co-morbid conditions may cause pregnant women to use multiple medications, although safety of such practice is poorly understood.OBJECTIVES: We investigated the influence of combined prescriptions of opioid analgesics and selective serotonin reuptake inhibitors (SSRIs) during pregnancy on two adverse birth outcomes.METHODS: We analysed Swedish population-based births (n = 688 914) between 2007 and 2013. Using national registers, we obtained data on filled medication prescriptions, birth outcomes, and a wide range of parental characteristics. We estimated preterm birth and small-for-gestational-age risk following independent or combined prescriptions of the two medications compared with no filled prescriptions for either medication. We adjusted for confounders using inverse probability of treatment weights.RESULTS: After adjusting for confounders, preterm birth risk was higher among women with opioid analgesic prescriptions only (5.9%; risk ratio [RR] 1.27, 95% confidence interval [CI] 1.22, 1.33), SSRIs only (6.2%; RR 1.34, 95% CI 1.27, 1.42), and both medications (7.8%; RR 1.70, 95% CI 1.47, 1.96) compared with unexposed women (4.6%). The interaction between the medications on preterm birth was small (risk difference [RD] 0.4%, 95% CI -0.8%, 1.6%); relative excess risk due to interaction [RERI] 0.09, 95% CI -0.17, 0.34; RR 1.00, 95% CI 0.85, 1.17). For small for gestational age, risk was approximately 2% across all groups, and there was no interaction between the medications (RD 0.3%, 95% CI -0.4%, 1.1%); RERI 0.15, 95% CI -0.16, 0.47; RR 1.15, 95% CI 0.87, 1.52).CONCLUSIONS: Compared with unexposed pregnancies, those with either medication alone had a small increased risk for preterm birth but no increased risk for small for gestational age. The magnitude of associations with combined exposure to both medications were not greater than the sum of the associations with each medication considered individually.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Rickert, Martin E.Department of Psychological & Brain Sciences, Indiana University-Bloomington, Bloomington, IN, USA
(författare)
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Quinn, Patrick D.Department of Applied Health Science, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA
(författare)
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Ludema, ChristinaDepartment of Epidemiology and Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA
(författare)
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Wiggs, Kelsey K.Department of Psychological & Brain Sciences, Indiana University-Bloomington, Bloomington, IN, USA
(författare)
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Larsson, Henrik,1975-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)hiln
(författare)
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Lichtenstein, PaulKarolinska Institutet
(författare)
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Almqvist, CatarinaKarolinska Institutet
(författare)
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Öberg, Anna SaraDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology, T.H. Chan School of Public Health, Harvard, Boston, MA, USA
(författare)
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D'Onofrio, Brian M.Karolinska Institutet
(författare)
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Department of Psychological & Brain Sciences, Indiana University-Bloomington, Bloomington, IN, USADepartment of Applied Health Science, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Paediatric and Perinatal Epidemiology: Blackwell Science Ltd.35:2, s. 184-1930269-50221365-3016
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