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Appetite disinhibit...
Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory
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- Brunner, Eric J. (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK
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- Maruyama, Koutatsu (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK; Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan; Laboratory of Community Health and Nutrition, Department of Bioscience, Graduate School of Agriculture, Ehime University, Matsuyama, Japan
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- Shipley, Martin (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK
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- Cable, Noriko (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK
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- Iso, Hiroyasu (författare)
- Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan
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- Hiyoshi, Ayako, 1972- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics
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- Stallone, Daryth (författare)
- Nutrepol, Merritt Island, FL, USA
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- Kumari, Meena (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK; Institute for Social and Economic Research, University of Essex, Colchester, UK
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- Tabak, Adam (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK; Department of Internal Medicine and Ocology, Faculty of Medicine, Semmelweis University, Budapest, Hungary; Department of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary
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- Singh-Manoux, Archana (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK; Epidemiology of Ageing and Neurodegenerative diseases, Université de Paris, Paris, France
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- Wilson, John (författare)
- North Devon Medical Education Centre, North Devon District Hospital, Barnstaple, UK
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- Langenberg, Claudia (författare)
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK
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- Wareham, Nick (författare)
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK
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- Boniface, David (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK
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- Hingorani, Aroon (författare)
- Institute of Cardiovascular Science, University College London, London, UK
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- Kivimäki, Mika (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK
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- Llewellyn, Clare (författare)
- Institute of Epidemiology and Health Care, University College London, London, UK
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(creator_code:org_t)
- 2021-01-14
- 2021
- Engelska.
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Ingår i: International Journal of Obesity. - : Nature Publishing Group. - 0307-0565 .- 1476-5497. ; 45, s. 758-765
- Relaterad länk:
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https://doi.org/10.1...
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND/OBJECTIVES: The mediating role of eating behaviors in genetic susceptibility to weight gain during mid-adult life is not fully understood. This longitudinal study aims to help us understand contributions of genetic susceptibility and appetite to weight gain.SUBJECTS/METHODS: We followed the body-mass index (BMI) trajectories of 2464 adults from 45 to 65 years of age by measuring weight and height on four occasions at 5-year intervals. Genetic risk of obesity (gene risk score: GRS) was ascertained, comprising 92 BMI-associated single-nucleotide polymorphisms and split at a median (=high and low risk). At the baseline, the Eating Inventory was used to assess appetite-related traits of 'disinhibition', indicative of opportunistic eating or overeating and 'hunger' which is susceptibility to/ability to cope with the sensation of hunger. Roles of the GRS and two appetite-related scores for BMI trajectories were examined using a mixed model adjusted for the cohort effect and sex.RESULTS: Disinhibition was associated with higher BMI (beta = 2.96; 95% CI: 2.66-3.25 kg/m(2)), and accounted for 34% of the genetically-linked BMI difference at age 45. Hunger was also associated with higher BMI (beta = 1.20; 0.82-1.59 kg/m(2)) during mid-life and slightly steeper weight gain, but did not attenuate the effect of disinhibition. CONCLUSIONS: Appetite disinhibition is most likely to be a defining characteristic of genetic susceptibility to obesity. High levels of appetite disinhibition, rather than hunger, may underlie genetic vulnerability to obesogenic environments in two-thirds of the population of European ancestry.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Brunner, Eric J.
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Maruyama, Koutat ...
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Shipley, Martin
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Cable, Noriko
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Iso, Hiroyasu
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Hiyoshi, Ayako, ...
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visa fler...
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Stallone, Daryth
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Kumari, Meena
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Tabak, Adam
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Singh-Manoux, Ar ...
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Wilson, John
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Langenberg, Clau ...
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Wareham, Nick
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Boniface, David
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Hingorani, Aroon
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Kivimäki, Mika
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Llewellyn, Clare
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visa färre...
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Örebro universitet