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- Tsoli, M.Endocrine Unit, 1st Department of Propaedeutic Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece (författare)
The efficacy of above-label doses of long-acting somatostatin analogues for the management of patients with gastroenteropancreatic tumors
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
- European Neuroendocrine Association,2021
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:oru-90433
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-90433URI
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- Språk:engelska
- Sammanfattning på:engelska
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- Introduction: Above-label doses of long-acting somatostatin analogues (SSAs) are increasingly used for the control of secretory syndrome or as anti-proliferative treatment in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs).Aim(s): The aim of this study was to evaluate the anti-proliferative effect of increased dose of SSAs in patients with GEP-NETs.Materials and methods: We collected retrospectively the data of patients with GEP-NETs that received SSAs every 3 or 2 weeks, after disease progression on standard 4-weekly doses. We analysed clinical, biochemical and radiographic response data and identified factors that may influence the outcome.Results: We analysed the data of 16 patients. 7 patients suffered from pancreatic NET (pNET) and 9 from small intestinal NET (si-NET). Indications for dose increase were radiographic progression (62,5%), increasing biomarkers (12,5%) or inadequate syndrome control (25%). Among patients with radiographic progression before the escalation of SSA dose, 3 had disease stabilization and 7 eventually progressed radiographically. Median PFSwas 36 months. PNETs were associated with a significantly lower PFS compared to si-NETs (P= 0.041). Patients with NET with a Ki-67 labelling index≤5 displayed a significantly higher PFS (P= 0.047). No significant difference was observed between patients who received above-label SSAs due to clinical/biochemical or radiographic response (P=0.1). In univariate analysis, the Ki-67≤5 was marginally associated with significantly longer PFS (P=0.05).Conclusion: The administration of above-label doses of SSAs maybe a valuable option in patients who progress on the standard 4-weekly regimen, especially in patients with si-NETs or a Ki-67 labelling index≤5.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- neuroendocrine tumor
- somatostatin analogues
- medical treatment
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Daskalakis, Kosmas,1979-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery(Swepub:oru)kds (författare)
- Koumarianou, A.Hematology-Oncology Unit, 4th Department of Internal Medicine, Attiko Hospital, National and Kapodistrian University of Athens, Athens, Greece (författare)
- Kolomodi, D.Endocrine Unit, 1st Department of Propaedeutic Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece (författare)
- Anagnostou, E.Endocrine Unit, 1st Department of Propaedeutic Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece (författare)
- Kaltsas, G.Endocrine Unit, 1st Department of Propaedeutic Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece (författare)
- Endocrine Unit, 1st Department of Propaedeutic Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, GreeceInstitutionen för medicinska vetenskaper (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Journal of neuroendocrinology (Print): European Neuroendocrine Association33:S1, s. 146-1460953-81941365-2826
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- Journal of neuroendocrinology (Print) (Sök värdpublikationen i LIBRIS)
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