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Quantitative T2* im...
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Lidén, Mats,1976-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Radiology
(författare)
Quantitative T2* imaging of iron overload in a non-dedicated center - Normal variation, repeatability and reader variation
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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Elsevier,2021
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-92234
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-92234URI
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https://doi.org/10.1016/j.ejro.2021.100357DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Patients with transfusion dependent anemia are at risk of complications from iron overload. Quantitative T2* magnetic resonance imaging (MRI) is the best non-invasive method to assess iron deposition in the liver and heart and to guide chelation therapy.Purpose: To investigate the image quality and inter-observer variations in T2* measurements of the myocardium and the liver, and to obtain the lower limit of cardiac and hepatic quantitative T2* values in patients without suspicion of iron overload.Material and methods: Thirty-eight patients referred for cardiac MRI were prospectively included in the study. Three patients were referred with, and 35 without suspicion of iron overload. Quantitative T2* parametric maps were obtained on a 1.5 T MRI system in the cardiac short axis and liver axial view. Two readers independently assessed the image quality and the representative and the lowest T2* value in the myocardium and the liver.Results: The normal range of representative T2* values in the myocardium and liver was 24-45 ms and 14-37 ms, respectively. None of the 35 participants (0 %, 95 % confidence interval 0-11 %) in the normal reference group demonstrated representative T2* values below previously reported lower limits in the myocardium (20 ms) or the liver (8 ms). Focal myocardial areas with T2* values near the lower normal range, 19-20 ms, were seen in two patients. The readers generally reported good image quality.Conclusion: T2* imaging for assessing iron overload can be performed in a non-dedicated center with sufficient image quality.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Adrian, DavidDepartment of Radiology, Örebro University Hospital, Region Örebro County, Sweden
(författare)
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Widell, JonasDepartment of Radiology, Örebro University Hospital, Region Örebro County, Sweden
(författare)
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Uggla, Bertil,1962-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medicine(Swepub:oru)bua
(författare)
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Thunberg, Per,1968-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Physics(Swepub:oru)prtg
(författare)
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Örebro universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European journal of radiology open: Elsevier82352-0477
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