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Effectiveness of Th...
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Albshesh, AhmadSheba Medical Center, Department of Gastroenterology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
(författare)
Effectiveness of Third-Class Biologic Treatment in Crohn's Disease : A Multi-Center Retrospective Cohort Study
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-06-29
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MDPI,2021
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-93212
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-93212URI
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https://doi.org/10.3390/jcm10132914DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Multiple studies have described the effectiveness of ustekinumab (UST) and vedolizumab (VDZ) in patients with Crohn's disease (CD) failing anti- Tumor necrosis factors (TNFs); however, the effectiveness of VDZ or UST as a third-class biologic has not yet been described.Aims and Methods: In this retrospective multicenter cohort study, we aimed to investigate the effectiveness of VDZ and UST as a third-class biologic in patients with CD.Results: Two-hundred and four patients were included; 156/204 (76%) patients received VDZ as a second- and UST as a third-class therapy (group A); the remaining 48/204 (24%) patients received UST as a second- and VDZ as a third-class therapy (group B). At week 16-22, 87/156 (55.5%) patients and 27/48 (56.2%) in groups A and B, respectively, responded to treatment (p = 0.9); 41/156 (26.2%) and 15/48 (31.2%) were in clinical remission (p = 0.5). At week 52; 89/103 (86%) patients and 25/29 (86.2%) of the patients with available data had responded to third-class treatment in groups A and B, respectively (p = 0.9); 31/103 (30%) and 47/29 (24.1%) were in clinical remission (p = 0.5).Conclusion: Third-class biological therapy was effective in more than half of the patients with CD. No differences in effectiveness were detected between the use of VDZ and UST as a third-class agent.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Taylor, JoshuaDepartment of Gastroenterology, Montreal General Hospital, Montreal QC, Canada
(författare)
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Savarino, Edoardo, VDivision of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy
(författare)
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Truyens, MarieIBD Unit, Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium
(författare)
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Armuzzi, AlessandroIBD Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy
(författare)
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Ribaldone, Davide G.Division of Gastroenterology, Department of Medical Sciences, University of Turin, Turin, Italy
(författare)
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Shitrit, Ariella Bar-GilShaare Zedek Medical Center, Faculty of Medicine, Digestive Diseases Institute, Hebrew University of Jerusalem, Jerusalem, Israel
(författare)
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Fibelman, MorineTel Aviv Medical Center, Department of Gastroenterology and Liver Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
(författare)
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Molander, PauliinaAbdominal Center, Department of Gastroenterology, Helsinki University Hospital, Helsinki, Finland
(författare)
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Liefferinckx, ClaireDepartment of Gastroenterology, Erasme University Hopital, Brussels, Belgium
(författare)
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Nancey, StephaneDepartment of Gastroenterology, Hospices Civils de Lyon, University Claude Bernard Lyon, Lyon, France; INSERM, U1111, CIRI, Lyon, France
(författare)
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Korani, MohamedDivision of Gastroenterology, The Pennine Acute Hospitals NHS Trust, Manchester, UK; Manchester Academic Health Sciences, University of Manchester, Manchester, UK
(författare)
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Rutka, MariannFirst Department of Medicine, University of Szeged, Szeged, Hungary
(författare)
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Barreiro-de Acosta, ManuelIBD Unit, Gastroenterology Department, University Hospital of Santiago de Compostela, Santiago, Spain
(författare)
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Domislovic, ViktorDepartment of Gastroenterology, Hepatology, and Nutrition, University Hospital Centre Zagreb, Zagreb, Croatia
(författare)
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Suris, GerardDigestive System Service, Bellvitge University Hospital, Catalan Institute of Health, Barcelona, Spain
(författare)
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Eriksson, Carl,1981-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology(Swepub:oru)clen
(författare)
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Alves, CatarinaDepartment of Gastroenterology, Centro Hospitalar São João, Porto, Portugal
(författare)
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Mpitouli, AfroditiDepartment of Gastroenterology, Venizeleion General Hospital, Heraklion, Crete, Greece
(författare)
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di Jiang, CarolineDepartment of Gastroenterology, Addenbrooke’s Hospital, Cambridge University Hospitals, Cambridge, UK
(författare)
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Tepes, KatjaUniversity Medical Centre Ljubljana, Department of Gastroenterology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
(författare)
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Coletta, MarinaDepartment of Hepatology and Clinical Gastroenterology, ASST Santi Paolo e Carlo-Ospedale San Polo Universitario Milano Mariabeatrice, Milan, Italy
(författare)
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Foteinogiannopoulou, KalliopiDepartment of Gastroenterology, University Hospital of Heraklion, Crete, Greece
(författare)
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Gisbert, Javier P.Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid, Madrid, Spain
(författare)
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Amir-Barak, HadarIBD Center, Division of Gastroenterology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
(författare)
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Attauabi, MohamedCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark
(författare)
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Seidelin, JakobDepartment of Gastroenterology, Herlev University Hospital, Copenhagen, Denmark
(författare)
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Afif, WaqqasDepartment of Gastroenterology, Montreal General Hospital, Montreal QC, Canada
(författare)
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Marinelli, CarlaDivision of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy
(författare)
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Lobaton, TrianaIBD Unit, Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium
(författare)
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Pugliese, DanielaIBD Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy
(författare)
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Maharshak, NitsanTel Aviv Medical Center, Department of Gastroenterology and Liver Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
(författare)
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Cremer, AnnelineDepartment of Gastroenterology, Erasme University Hopital, Brussels, Belgium
(författare)
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Limdi, Jimmy K.Division of Gastroenterology, The Pennine Acute Hospitals NHS Trust, Manchester, UK; Manchester Academic Health Sciences, University of Manchester, Manchester, UK
(författare)
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Molnár, TamásFirst Department of Medicine, University of Szeged, Szeged, Hungary
(författare)
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Otero-Alvarin, BorjaIBD Unit, Gastroenterology Department, University Hospital of Santiago de Compostela, Santiago, Spain
(författare)
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Krznaric, ZeljkoDepartment of Gastroenterology, Hepatology, and Nutrition, University Hospital Centre Zagreb, Zagreb, Croatia
(författare)
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Magro, FernandoDepartment of Gastroenterology, Centro Hospitalar São João, Porto, Portugal
(författare)
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Karmiris, KonstantinosDepartment of Gastroenterology, Venizeleion General Hospital, Heraklion, Crete, Greece
(författare)
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Raine, TimDepartment of Gastroenterology, Addenbrooke’s Hospital, Cambridge University Hospitals, Cambridge, UK
(författare)
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Drobne, DavidUniversity Medical Centre Ljubljana, Department of Gastroenterology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
(författare)
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Koutroubakis, IoannisDepartment of Gastroenterology, University Hospital of Heraklion, Crete, Greece
(författare)
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Chaparro, MariaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid, Madrid, Spain
(författare)
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Yanai, HenitIBD Center, Division of Gastroenterology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
(författare)
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Burisch, JohanCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark
(författare)
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Kopylov, UriSheba Medical Center, Department of Gastroenterology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
(författare)
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Sheba Medical Center, Department of Gastroenterology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, IsraelDepartment of Gastroenterology, Montreal General Hospital, Montreal QC, Canada
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Clinical Medicine: MDPI10:132077-0383
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Till lärosätets databas
- Av författaren/redakt...
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Albshesh, Ahmad
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Taylor, Joshua
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Savarino, Edoard ...
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Truyens, Marie
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Armuzzi, Alessan ...
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Ribaldone, David ...
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visa fler...
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Shitrit, Ariella ...
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Fibelman, Morine
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Molander, Paulii ...
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Liefferinckx, Cl ...
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Nancey, Stephane
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Korani, Mohamed
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Rutka, Mariann
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Barreiro-de Acos ...
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Domislovic, Vikt ...
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Suris, Gerard
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Eriksson, Carl, ...
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Alves, Catarina
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Mpitouli, Afrodi ...
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di Jiang, Caroli ...
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Tepes, Katja
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Coletta, Marina
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Foteinogiannopou ...
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Gisbert, Javier ...
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Amir-Barak, Hada ...
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Attauabi, Mohame ...
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Seidelin, Jakob
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Afif, Waqqas
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Marinelli, Carla
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Lobaton, Triana
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Pugliese, Daniel ...
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Maharshak, Nitsa ...
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Cremer, Anneline
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Limdi, Jimmy K.
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Molnár, Tamás
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Otero-Alvarin, B ...
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Krznaric, Zeljko
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Magro, Fernando
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Karmiris, Konsta ...
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Raine, Tim
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Drobne, David
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Koutroubakis, Io ...
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Chaparro, Maria
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Yanai, Henit
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Burisch, Johan
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Kopylov, Uri
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