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Pathogenesis Of Mic...
Pathogenesis Of Microscopic Colitis : A Systematic Review
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- Zabana, Yamile (författare)
- Hospital Universitari Mútua de Terrassa, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain,Hosp Univ Mutua Terrassa, Spain; Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain
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- Tontini, Gian (författare)
- Department of Pathophysiology and Transplantation, University of Milan and Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Milan, Italy,Univ Milan, Italy; Fdn IRCCS Ca Granda Osped Maggiore Policlin, Italy
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- Hultgren Hörnquist, Elisabeth, 1965- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Sweden
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- Skonieczna-Żydecka, Karolina (författare)
- Department of Biochemical Sciences, Pomeranian Medical University, Szczecin, Poland,Pomeranian Med Univ, Poland
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- Latella, Giovanni (författare)
- Gastroenterology Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy
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- Østvik, Ann Elisabeth (författare)
- Department of Clinical and Molecular Medicine [IKOM], Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim, Norway; Department of Gastroenterology and Hepatology, Clinic of Medicine, St. Olav's University Hospital, Norway,Norwegian Univ Sci & Technol, Norway; St Olavs Univ Hosp, Norway
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- Marlicz, Wojciech (författare)
- Department of Gastroenterology, Pomeranian Medical University; The Centre for Digestive Diseases Endoklinika, Szczecin-Poland,Pomeranian Med Univ, Poland; Ctr Digest Dis Endoklin, Poland
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- D'Amato, Mauro (författare)
- Karolinska Institutet
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- Arias, Angel (författare)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain; Research Unit, Hospital General Mancha Centro, Alcázar de San Juan, Ciudad Real-Spain, Spain,Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain; Hosp Gen Mancha Ctr, Spain
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- Mielhke, Stephan (författare)
- Centre for Digestive Diseases, Internal Medicine Centre Eppendorf & Endoscopy Centre, University Hospital Hamburg Eppendorf, Germany,Univ Hosp Hamburg Eppendorf, Germany; Univ Hosp Hamburg Eppendorf, Germany
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- Münch, Andreas (författare)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken
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- Fernández-Bañares, Fernando (författare)
- Hospital Universitari Mútua de Terrassa, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain,Hosp Univ Mutua Terrassa, Spain; Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain
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- Lucendo, Alfredo J. (författare)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain; Hospital General de Tomelloso-Spain and Instituto de Investigación Sanitaria Princesa (IIS-IP),Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain; Hosp Gen Tomelloso Spain, Spain; Inst Invest Sanitaria Princesa IIS IP, Spain
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(creator_code:org_t)
- 2021-07-17
- 2022
- Engelska.
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Ingår i: Journal of Crohn's & Colitis. - Oxford, United Kingdom : Elsevier. - 1873-9946 .- 1876-4479. ; 16:1, s. 143-161
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Whereas the exact aetiology of microscopic colitis [MC] remains unknown, a dysregulated immune response to luminal factors or medications is the most accepted pathogenesis hypothesis.Methods: We conducted a systematic review of the pathogenesis of MC. We applied the Joanna Briggs Institute methodologies and the PRISMA statement for the reporting of systematic reviews [PROSPERO Trial Identifier: CRD42020145008]. Populations, Exposure of interest, and Outcome [PEO] questions were used to explore the following topics in MC: 1] intestinal luminal factors; 2] autoimmunity; 3] innate immunity; 4] adaptive immunity; 5] extracellular matrix; 6] genetic risk factors; and 7] mechanism of diarrhoea. A search was done in PubMed, Embase, and Web of Science up to February 2020. A narrative description was performed explaining the findings for each aspect of MC aetiopathogenesis.Results: Thirty-eight documents provided evidence for PEO1, 100 for PEO2, 72 for PEO3 and 4, 38 for PEO5, 20 for PEO6, and 23 for PEO7. The majority of documents were cohorts, case reports, and case series, with a few case-control and some experimental studies. Consistency among data provided by different studies was considered to support pathogenetic hypotheses. MC is a multifactorial disease believed to involve innate and adaptive immune responses to luminal factors, genetic risk, autoimmunity, and extracellular matrix alterations, all contributing by varied mechanisms to watery diarrhoea.Conclusions: This is the first systematic review on the aetiology of MC supporting the notion that MC is a multifactorial disease. However, high-profile studies are lacking, and most evidence derives from small heterogeneous studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Adaptive immunity
- aetiology
- autoimmunity
- collagenous colitis
- diarrhoea mechanism
- extracellular matrix remodelling
- genetic risk factors
- innate immunity
- intestinal luminal factors
- lymphocytic colitis
- microscopic colitis
- pathogenesis
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Till lärosätets databas
- Av författaren/redakt...
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Zabana, Yamile
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Tontini, Gian
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Hultgren Hörnqui ...
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Skonieczna-Żydec ...
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Latella, Giovann ...
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Østvik, Ann Elis ...
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visa fler...
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Marlicz, Wojciec ...
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D'Amato, Mauro
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Arias, Angel
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Mielhke, Stephan
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Münch, Andreas
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Fernández-Bañare ...
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Lucendo, Alfredo ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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Journal of Crohn ...
- Av lärosätet
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Örebro universitet
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Linköpings universitet
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Karolinska Institutet