Sökning: onr:"swepub:oai:DiVA.org:oru-93496" >
Differential effect...
-
Papapavlou, GeorgiaLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
(författare)
Differential effects of estradiol and progesterone on human T cell activation in vitro
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
-
2021-07-26
-
Wiley-VCH Verlagsgesellschaft,2021
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:oru-93496
-
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-93496URI
-
https://doi.org/10.1002/eji.202049144DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-178460URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Funding agencies:Swedish Lions Research FoundationSwedish Foundation for MS Research
-
Funding Agencies|Swedish Foundation for Strategic ResearchSwedish Foundation for Strategic Research [SB16-0011]; Swedish Research CouncilSwedish Research CouncilEuropean Commission [2018-02776]; Swedish Lions Research Foundation; Swedish Society of Medicine [SLS-879791]; NEURO Sweden [F2018-0052]; Swedish Foundation for MS Research
-
Estradiol (E2) and progesterone (P4) are steroid hormones important for the regulation of immune responses during pregnancy. Their increasing levels coincide with an improvement of T cell-mediated diseases such as multiple sclerosis (MS). Although immune-endocrine interactions are involved in this phenomenon, the relative contribution of hormones is not known. We here report a direct comparison of E2- and P4-mediated effects on human CD4+ T cells, key cells in immune regulation. T cells were stimulated to obtain different activation levels and exposed to a broad range of hormone concentrations. Activation level was assessed by CD69/CD25 expression by flow cytometry, and secreted proteins (n = 196) were measured in culture supernatants using proximity extension assay and electrochemiluminescence immunoassay. We found that in low activated cells, pregnancy-relevant E2 concentrations increased activation and the secretion of several immune- and inflammation-related proteins. P4, on the other hand, showed a biphasic pattern, where serum-related concentrations upregulated activation and protein secretion while placenta-relevant concentrations induced a prominent dampening irrespective of the initial activation level. Our results demonstrate the importance of P4 as a major hormone in the immune modulation of T cells during pregnancy and emphasize the need to further evaluate its potency in the treatment of diseases like MS.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Hellberg, SandraLinköpings universitet,Bioinformatik,Tekniska fakulteten(Swepub:liu)sanhe13
(författare)
-
Raffetseder, JohannaLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)johra57
(författare)
-
Brynhildsen, Jan,1962-Linköpings universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Obstetrics and Gynecology, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; Department of Obstetrics and Gynecology, Faculty of Medicine, Örebro University, Örebro, Sweden,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US,Orebro Univ, Sweden(Swepub:liu)janbr05
(författare)
-
Gustafsson, MikaLinköpings universitet,Bioinformatik,Tekniska fakulteten(Swepub:liu)mikgu75
(författare)
-
Jenmalm, MariaLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)marje18
(författare)
-
Ernerudh, JanLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin(Swepub:liu)janer15
(författare)
-
Linköpings universitetAvdelningen för inflammation och infektion
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:European Journal of Immunology: Wiley-VCH Verlagsgesellschaft51:10, s. 2430-24400014-29801521-4141
Internetlänk
Hitta via bibliotek
Till lärosätets databas