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Risk of hepatocellu...
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Kamal, HabibaDepartment of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden
(författare)
Risk of hepatocellular carcinoma in hepatitis B and D virus co-infected patients : A systematic review and meta-analysis of longitudinal studies
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-07-28
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John Wiley & Sons,2021
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-93514
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-93514URI
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https://doi.org/10.1111/jvh.13577DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147205076URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:for swepub-publicationtype
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Funding agencies:Foundation of ALFFoundation of Becas-Chile, (ANID, National Agency of Investigation and Research, Chile)Center for innovative medicine CIMED 20180889 AbbVieGilead Sciences
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Hepatitis D virus (HDV) infection causes a severe chronic viral hepatitis with accelerated development of liver cirrhosis and decompensation, but whether it further increases the risk of hepatocellular carcinoma (HCC) is unclear. We performed a comprehensive systematic review of the published literature and meta-analysis to assess the risk of HCC in HDV and hepatitis B virus (HBV) co-infected, compared to HBV mono-infected patients. The study was conducted per a priori defined protocol, including only longitudinal studies, thus excluding cross-sectional studies. Random-effects models were used to determine aggregate effect sizes (ES) with 95% confidence intervals (CI). Meta-regression was used to examine the associations among study level characteristics. Twelve cohort studies comprising a total of 6099 HBV/HDV co-infected and 57,620 chronic HBV mono-infected patients were analysed. The overall pooled ES showed that HBV/HDV co-infected patients were at 2-fold increased risk of HCC compared to HBV mono-infected patients (ES = 2.12, 95% CI 1.14-3.95, I2 = 72%, N = 12). A six-fold significant increased risk of HCC was noted among HIV/HBV/HDV triple-infected, compared to HIV/HBV co-infected patients. The magnitude of ES did not differ significantly after adjustment for study design and quality, publication year and follow-up duration in univariable meta-regression analysis. This systematic review and meta-analysis shows that infection with HDV is associated with a 2-fold higher risk of HCC development compared to HBV mono-infection. HCC surveillance strategies taking this increased risk into account, and new treatment options against HDV, are warranted.
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Fornes, RominaCentre for Translational Microbiome Research (CTMR), Department of Microbiology, Tumor and Cell biology (MTC), Karolinska Institutet, Stockholm, Sweden
(författare)
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Simin, JohannaCentre for Translational Microbiome Research (CTMR), Department of Microbiology, Tumor and Cell biology (MTC), Karolinska Institutet, Stockholm, Sweden
(författare)
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Stål, PerDepartment of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Upper GI, Karolinska University Hospital, Stockholm, Sweden
(författare)
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Duberg, Ann-Sofi,Docent,1957-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious Diseases(Swepub:oru)adg
(författare)
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Brusselaers, NeleKarolinska Institutet
(författare)
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Aleman, SooKarolinska Institutet
(författare)
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Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Karolinska Institutet, Stockholm, SwedenCentre for Translational Microbiome Research (CTMR), Department of Microbiology, Tumor and Cell biology (MTC), Karolinska Institutet, Stockholm, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Viral Hepatitis: John Wiley & Sons28:10, s. 1431-14421352-05041365-2893
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