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Dermal exposure to ...
Dermal exposure to cobalt studied in vitro in keratinocytes : effects of cobalt exposure on inflammasome activated cytokines, and mRNA response
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- Klasson, Maria, 1977- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Occupational and Environmental Medicine,Inflammatory Response and Infection Susceptibility Centre (iRiSC)
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- Lindberg, Magnus, 1952- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Dermatology, University Hospital Örebro, Örebro, Sweden,Inflammatory Response and Infection Susceptibility Centre (iRiSC)
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- Westberg, Håkan, 1949- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Occupational and Environmental Medicine,Inflammatory Response and Infection Susceptibility Centre (iRiSC)
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- Bryngelsson, Ing-Liss (författare)
- Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Tuerxun, Kaya, 1981- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC)
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- Persson, Alexander, 1978- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC)
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- Särndahl, Eva, 1963- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC)
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(creator_code:org_t)
- Taylor & Francis, 2021
- 2021
- Engelska.
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Ingår i: Biomarkers. - : Taylor & Francis. - 1354-750X .- 1366-5804. ; 26:8, s. 674-684
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Cobalt is a dermal sensitizer, and keratinocytes respond to cobalt exposure by releasing proinflammatory mediators, regulating the immune response.OBJECTIVE: To determine the effect of cobalt on the inflammasome associated cytokine- and gene expression in cultured human keratinocytes (HaCaT). Cultivation in low- or high calcium conditions model separate differentiation states of keratinocytes in the skin.METHOD: HaCaT cells in two different states of differentiation were exposed to cobalt chloride and caspase-1 activity as well as the production of IL-1 beta, IL-18 and gene expression of IL1B, IL18, NLRP3, CASP1, and PYCARD was quantified. RESULTS: High cobalt chloride exposure mediated significant increase in caspase-1 activity, cytokine levels, and IL1B and NLRP3 expression with a corresponding regulatory decrease for CASP1 and PYCARD expression. No difference between high- and low calcium culturing conditions modelling differentiation states was detected.CONCLUSIONS: Our data suggest that HaCaT cells respond with inflammmasome associated activity upon cobalt exposure in a concentration-dependent manner. These mechanisms could be of importance for the understanding of the pathophysiology behind allergic sensitization to dermal cobalt exposure.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Nyckelord
- CoCl2
- HaCaT
- IL-18
- IL-1β
- NLRP3 inflammasome
- caspase-1
- skin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Klasson, Maria, ...
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Lindberg, Magnus ...
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Westberg, Håkan, ...
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Bryngelsson, Ing ...
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Tuerxun, Kaya, 1 ...
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Persson, Alexand ...
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Särndahl, Eva, 1 ...
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Örebro universitet