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Mortality in Eosino...
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Röjler, Lovisa,1983-Department of Pediatrics, Örebro University Hospital, Sweden
(författare)
Mortality in Eosinophilic Esophagitis - a nationwide, population-based matched cohort study from 2005 to 2017
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-08-31
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Uppsala Medical Society,2021
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-94670
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-94670URI
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https://doi.org/10.48101/ujms.v126.7688DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147615750URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding agency:Örebro University Hospital
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Background: There is a lack of knowledge about mortality in eosinophilic esophagitis (EoE). Therefore, this study aimed to examine the mortality in EoE.Methods: A nationwide, population- based matched cohort study was conducted of all EoE patients in Sweden diagnosed between July 2005 and December 2017. Individuals with EoE (n = 1,625) were identified through prospectively recorded histopathology codes from all gastrointestinal pathology-reports in Sweden, representing 28 pathology departments (the ESPRESSO study). Each individual with EoE was then matched with up to five reference individuals from the general population (n = 8,003) for age, sex, year of birth, and place of residence. We used the Cox proportional hazard modeling to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (95% CI) while adjusting for other potential confounders. In sensitivity analyses, mortality in EoE patients was compared with mortality in their siblings.Results: Through December 2017, 34 deaths were confirmed in EoE patients (4.60 per 1,000 person-years) compared with 165 in reference individuals (4.57 per 1,000 person-years). This rate corresponds to an aHR of 0.97 (95% CI = 0.67-1.40). HRs were similar in males (aHR = 1.00 [0.66-1.51]) and females (aHR = 0.92 [0.38-2.18]). We observed no increased risk in mortality due to esophageal or other gastrointestinal cancers in patients with EoE (aHR = 1.02 [0.51- 2.02]). Mortality was similar in EoE patients and their siblings (aHR = 0.91 [0.44-1.85]).Conclusion: In this nationwide, population-based matched cohort study in Sweden, there was no -increased risk of death in patients with EoE compared with their siblings and the general population.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Garber, John J.Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA
(författare)
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Roelstraete, BjornKarolinska Institutet
(författare)
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Walker, Marjorie M.Department Anatomical Pathology, University of Newcastle, Faculty of Health and Medicine, School of Medicine and Public Health Callaghan NSW, Australia
(författare)
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Ludvigsson, Jonas F.,1969-Karolinska Institutet,Region Örebro län,Department of Pediatrics, Örebro University Hospital, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, City Hospital, Nottingham, UK; Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA(Swepub:oru)jsln
(författare)
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Department of Pediatrics, Örebro University Hospital, SwedenGastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Upsala Journal of Medical Sciences: Uppsala Medical Society126:10300-97342000-1967
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