Sökning: onr:"swepub:oai:DiVA.org:oru-95187" >
The prognostic and ...
The prognostic and predictive impact of low estrogen receptor expression in early breast cancer : a systematic review and meta-analysis
-
- Paakkola, N.-M. (författare)
- School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Sch Med Sci, Fac Med & Hlth, Örebro, Sweden.
-
- Karakatsanis, Andreas (författare)
- Uppsala universitet,Endokrinkirurgi
-
- Mauri, D. (författare)
- Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece,Univ Ioannina, Sch Hlth Sci, Fac Med, Ioannina, Greece.
-
visa fler...
-
- Foukakis, T. (författare)
- Karolinska Institutet
-
- Valachis, Antonis, 1984- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Oncology,Örebro Univ, Fac Med & Hlth, Dept Oncol, S-70182 Örebro, Sweden.
-
visa färre...
-
School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden Örebro Univ, Sch Med Sci, Fac Med & Hlth, Örebro, Sweden (creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
-
Ingår i: ESMO Open. - : Elsevier. - 2059-7029. ; 6:6
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
http://www.esmoopen....
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- INTRODUCTION: Traditionally, estrogen receptor (ER)-positive breast cancer has been defined as tumors with ≥1% positive for ER. The updated American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) guidelines recommend that tumors with ER expression of 1%-10% should be classified as ER-low-positive, recognizing the limited clinical evidence on the prognostic and predictive role of low ER expression. We aimed to investigate the predictive role of ER-low expression to neoadjuvant chemotherapy (NeoCT) and the prognostic significance of ER-low expressing breast tumors compared with ER-positive or ER-negative breast tumors.METHODS: A meta-analysis was conducted using the Meta-analyses Of Observational Studies in Epidemiology (MOOSE) guidelines and eligible articles were identified on PubMed and ISI Web of Science databases. The primary outcome was pathologic complete response and secondary outcomes were disease-free survival (DFS) and overall survival (OS). Twelve retrospective cohort studies were included in the meta-analysis. NeoCT resulted in higher pathologic complete response among patients with ER-low expression compared with ER-positive and comparable to ER-negative. Patients with ER-low breast cancer had a statistically significant worse DFS and OS compared with patients with ER-positive breast cancer, whereas no difference in DFS or OS was observed between ER-low and ER-negative subgroups.DISCUSSION: The current evidence suggests that ER-low breast cancer has a more similar outcome to ER-negative than to ER-positive breast cancer in terms of DFS and OS. ER-low expression seems also to have a predictive role regarding NeoCT. Considering the certainty of current evidence categorized as low to moderate, our results urge the need for well-designed prospective studies investigating the molecular background and the most appropriate treatment strategy for ER-low expressing breast cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- ER-low
- adjuvant
- breast cancer
- meta-analysis
- neoadjuvant chemotherapy
- prognosis
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
Till lärosätets databas