GENOMIC EPIDEMIOLOGY OF NEISSERIA GONORRHOEAE ISOLATES IN SWEDEN-2016 NATIONAL STUDY

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Fältnamn	Indikatorer	Metadata
000		04955naa a2200373 4500
001		oai:DiVA.org:oru-95229
003		SwePub
008		211027s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-952292 URI
024	7	a https://doi.org/10.1136/sextrans-2021-sti.3532 DOI
040		a (SwePub)oru
041		a engb eng
042		9 SwePub
072	7	a vet2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Hadad, Ronza,d 1984-u Örebro universitet,Institutionen för medicinska vetenskaper,WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections; National Reference Laboratory for STIs, Department of Laboratory Medicine4 aut0 (Swepub:oru)rahd
245	1 0	a GENOMIC EPIDEMIOLOGY OF NEISSERIA GONORRHOEAE ISOLATES IN SWEDEN-2016 NATIONAL STUDY
264		c 2021-07-06
264	1	b BMJ Publishing Group Ltd,c 2021
338		a print2 rdacarrier
520		a Background: The number of reported cases of gonorrhoea in Sweden continuously increased from an incidence of 7.8 per 100 000 inhabitants in 2009 to 31.4 in 2019. The largest increase in incidence was observed during 2016–2017. No national molecular epidemiological study investigating the population of N. gonorrhoeae circulating in Sweden has been performed in the last two decades. Our aim was to examine the antimicrobial resistance (AMR) and genome-based epidemiology, in conjunction to patient epidemiological data, of all gonococcal isolates (n=1279; one isolate per case) from gonorrhoea cases in Sweden during 2016.Methods: AMR testing was performed using Etest, and MICs were interpreted using current clinical resistance breakpoints from EUCAST. All isolates were whole genome sequenced using Illumina HiSeq X platform. Patient epidemiological data was obtained from the Public Health Agency of Sweden.Results: The gonorrhoea patients consisted of 252 (19.7%) women and 1027 men (80.3%). The medium age of the women was 27.4 years and of the men 32.1 years. Regarding sexual orientation, 619 (48.4%) reported homosexual, 605 (47.3%) heterosexual, 31 (2.4%) bisexual, and 24 (1.9%) did not report. Most prevalent countries of infection were Sweden (n=875, 68.4%), followed by Thailand (n=70, 5.5%) and Germany (n=32, 2.5%).Overall, the phenotypic AMR was as follows: ceftriaxone and spectinomycin (0%), cefixime (1.7%), azithromycin (1.3%) and ciprofloxacin (51.1%). A high concordance between phenotypic AMR and molecular AMR determinants was found. Results from the genome-based epidemiology are currently in final analysis.Conclusions: AMR in N. gonorrhoeae in Sweden remains low, in particular to ceftriaxone and azithromycin that is recommended internationally for dual therapy. The incidence increases in Sweden appear to be driven by increased spread among men-who-have-sex-with-men but also younger heterosexuals of both genders. This is the first national genome-based epidemiological study for N. gonorrhoeae in Sweden and final genomic results are pending.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
700	1	a Golparian, Daniel,d 1984-u Örebro universitet,Institutionen för medicinska vetenskaper,WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections; National Reference Laboratory for STIs, Department of Laboratory Medicine4 aut0 (Swepub:oru)degn
700	1	a Velicko, I.u Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden4 aut
700	1	a Lindroth, Y.u Department of Laboratory Medicine, Medical Microbiology, Lund University, Skåne Laboratory Medicine, Lund, Sweden4 aut
700	1	a Ohlsson, A.u Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden4 aut
700	1	a Fredlund, H.u WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Örebro, Sweden; National Reference Laboratory for STIs, Department of Laboratory Medicine, Örebro, Sweden; Faculty of Medicine and Health, Örebro University, Örebro, Sweden4 aut
700	1	a Unemo, Magnus,d 1970-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections; National Reference Laboratory for STIs, Department of Laboratory Medicine4 aut0 (Swepub:oru)muo
710	2	a Örebro universitetb Institutionen för medicinska vetenskaper4 org
773	0	t Sexually Transmitted Infectionsd : BMJ Publishing Group Ltdg 97:Suppl. 1, s. A135-A135q 97:Suppl. 1<A135-A135x 1368-4973x 1472-3263
856	4	u https://sti.bmj.com/content/sextrans/97/Suppl_1/A135.1.full.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-95229
856	4 8	u https://doi.org/10.1136/sextrans-2021-sti.353

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