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Sex-Specific Metabo...
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Xu, JinInstitute of Pharmaceutical Science, King's College London, London, UK; Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK
(författare)
Sex-Specific Metabolic Pathways Were Associated with Alzheimer's Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-11-03
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MDPI,2021
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-95676
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-95676URI
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https://doi.org/10.3390/biomedicines9111610DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:148579020URI
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https://gup.ub.gu.se/publication/310881URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BACKGROUND: physiological differences between males and females could contribute to the development of Alzheimer's Disease (AD). Here, we examined metabolic pathways that may lead to precision medicine initiatives.METHODS: We explored whether sex modifies the association of 540 plasma metabolites with AD endophenotypes including diagnosis, cerebrospinal fluid (CSF) biomarkers, brain imaging, and cognition using regression analyses for 695 participants (377 females), followed by sex-specific pathway overrepresentation analyses, APOE ε4 stratification and assessment of metabolites' discriminatory performance in AD.RESULTS: In females with AD, vanillylmandelate (tyrosine pathway) was increased and tryptophan betaine (tryptophan pathway) was decreased. The inclusion of these two metabolites (area under curve (AUC) = 0.83, standard error (SE) = 0.029) to a baseline model (covariates + CSF biomarkers, AUC = 0.92, SE = 0.019) resulted in a significantly higher AUC of 0.96 (SE = 0.012). Kynurenate was decreased in males with AD (AUC = 0.679, SE = 0.046).CONCLUSIONS: metabolic sex-specific differences were reported, covering neurotransmission and inflammation pathways with AD endophenotypes. Two metabolites, in pathways related to dopamine and serotonin, were associated to females, paving the way to personalised treatment.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Green, RebeccaInstitute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK; NIHR Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
(författare)
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Kim, MinSteno Diabetes Center, Gentofte, Denmark
(författare)
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Lord, JodieInstitute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK
(författare)
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Ebshiana, AmeraInstitute of Pharmaceutical Science, King's College London, London, UK
(författare)
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Westwood, SarahDepartment of Psychiatry, University of Oxford, Oxford, UK
(författare)
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Baird, Alison L.Department of Psychiatry, University of Oxford, Oxford, UK
(författare)
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Nevado-Holgado, Alejo J.Department of Psychiatry, University of Oxford, Oxford, UK
(författare)
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Shi, LiuDepartment of Psychiatry, University of Oxford, Oxford, UK
(författare)
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Hye, AbdulInstitute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK
(författare)
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Snowden, Stuart G.Institute of Pharmaceutical Science, King's College London, London, UK
(författare)
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Bos, IsabelleAlzheimer Center, VU University Medical Center, Amsterdam, The Netherlands; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
(författare)
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Vos, Stephanie J. B.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
(författare)
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Vandenberghe, RikAlzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
(författare)
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Teunissen, Charlotte E.Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
(författare)
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Kate, Mara TenAlzheimer Center, VU University Medical Center, Amsterdam, The Netherlands; Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
(författare)
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Scheltens, PhilipAlzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
(författare)
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Gabel, SilvyDepartment of Clinical Chemistry, Neurochemistry Laboratory, Amsterdam Neuroscience, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, The Netherlands; Department of Neurosciences, Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium; University Hospital Leuven, Leuven, Belgium
(författare)
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Meersmans, KarenDepartment of Neurosciences, Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium; University Hospital Leuven, Leuven, Belgium
(författare)
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Blin, OlivierClinical Pharmacology & Pharmacovigilance Department, Aix-Marseille University-CNRS, Marseille, France
(författare)
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Richardson, JillNeurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK
(författare)
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De Roeck, Ellen ElisaCenter for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
(författare)
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Engelborghs, SebastiaanReference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; Department of Neurology and Center for Neurosciences (C4N), UZ Brussel and Vrije Universiteit Brussel (VUB), 1050 Brussels, Belgium
(författare)
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Sleegers, KristelDepartment of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, University of Antwerp, Antwerp, Belgium; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium
(författare)
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Bordet, RégisDepartment of Medical Pharmacology, Université de Lille, Lille, France
(författare)
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Rami, LorenaAlzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic of Barcelona, August Pi Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain
(författare)
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Kettunen, PetronellaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xketpe
(författare)
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Tsolaki, Magda1st Department of Neurology, AHEPA University Hospital, Thessaloniki, Greece
(författare)
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Verhey, Frans R. J.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
(författare)
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Alcolea, DanielSant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
(författare)
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Lleó, AlbertoSant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
(författare)
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Peyratout, GwendolineLausanne University Hospital, Lausanne, Switzerland
(författare)
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Tainta, MikelFundación CITA-Alzhéimer Fundazioa, San Sebastian, Spain
(författare)
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Johannsen, PeterDanish Dementia Research Centre, Rigshospitalet, Copenhagen, Denmark
(författare)
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Freund-Levi, Yvonne,1956-Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK(Swepub:oru)yfi
(författare)
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Frölich, LutzDepartment of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
(författare)
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Dobricic, ValerijaLübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany
(författare)
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Frisoni, Giovanni B.Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
(författare)
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Molinuevo, José LuisAlzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic of Barcelona, August Pi Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain
(författare)
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Wallin, Anders,1950Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap)(Swepub:gu)xwaand
(författare)
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Popp, JuliusOld Age Psychiatry, Department of Psychiatry, University Hospital Lausanne, Lausanne, Switzerland; Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zürich, Switzerland
(författare)
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Martinez-Lage, PabloCenter for Research and Advanced Therapies, CITA-Alzheimer Foundation, San Sebastian, Spain
(författare)
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Bertram, LarsLübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany; Department of Psychology, University of Oslo, Oslo, Norway
(författare)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(författare)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(författare)
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Streffer, JohannesReference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
(författare)
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Visser, Pieter JelleAlzheimer Center, VU University Medical Center, Amsterdam, The Netherlands; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
(författare)
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Lovestone, SimonInstitute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK; Department of Psychiatry, University of Oxford, Oxford, UK; Janssen-Cilag UK Ltd., Oxford, UK
(författare)
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Proitsi, PetroulaInstitute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK
(författare)
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Legido-Quigley, CristinaInstitute of Pharmaceutical Science, King's College London, London, UK; Steno Diabetes Center, Gentofte, Denmark
(författare)
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The European Medical Information Framework Consortium, -
(bidragsgivare)
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Institute of Pharmaceutical Science, King's College London, London, UK; Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UKInstitute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK; NIHR Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
(creator_code:org_t)
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Ingår i:Biomedicines: MDPI9:112227-9059
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Xu, Jin
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Green, Rebecca
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Kim, Min
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Lord, Jodie
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Ebshiana, Amera
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Westwood, Sarah
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Baird, Alison L.
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Nevado-Holgado, ...
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Shi, Liu
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Hye, Abdul
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Bos, Isabelle
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Vos, Stephanie J ...
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Vandenberghe, Ri ...
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Teunissen, Charl ...
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Kate, Mara Ten
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Scheltens, Phili ...
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Gabel, Silvy
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Meersmans, Karen
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Blin, Olivier
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Richardson, Jill
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De Roeck, Ellen ...
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Engelborghs, Seb ...
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Sleegers, Kriste ...
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Bordet, Régis
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Rami, Lorena
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Kettunen, Petron ...
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Tsolaki, Magda
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Verhey, Frans R. ...
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Alcolea, Daniel
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Lleó, Alberto
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Peyratout, Gwend ...
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Tainta, Mikel
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Johannsen, Peter
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Freund-Levi, Yvo ...
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Frölich, Lutz
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Molinuevo, José ...
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Popp, Julius
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Streffer, Johann ...
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Visser, Pieter J ...
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