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Sökning: onr:"swepub:oai:DiVA.org:oru-97682" > Alcohol Consumption...

  • Niccum, BlakeDepartment of Internal Medicine, Massachusetts General Hospital, Boston MA, USA (författare)

Alcohol Consumption is Associated With An Increased Risk of Microscopic Colitis : Results From 2 Prospective US Cohort Studies

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2021-09-02
  • Lippincott-Raven Publishers,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-97682
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-97682URI
  • https://doi.org/10.1093/ibd/izab220DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148766383URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA)R01 AG068390 UM1 CA186107 U01 CA176726  Janssen corporationCrohn's and Colitis FoundationBeker FoundationGeneral Electric
  • Background: No dietary factors have yet been shown to conclusively impact the incidence of microscopic colitis (MC). Here, we sought to examine the relationship between alcohol intake and the risk of MC.Methods: We conducted a prospective cohort study of 209,902 participants (age range, 28.5-66.7 years) enrolled in the Nurses' Health Study (NHS) and Nurses' Health Study II (NHSII). Validated data on alcohol consumption were collected at baseline in 1986 in the NHS and 1991 in the NHSII and updated every 4 years. Diagnoses of MC were confirmed via review of histopathology data. We used Cox proportional hazards modeling to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs).Results: Through 2016 in the NHS and 2017 in the NHSII, we confirmed 352 incident cases of MC over 4,994,324 person-years. Higher alcohol consumption was associated with an increased risk of MC (P-trend < .001). Compared to non-users, the aHRs of MC were 1.20 (95% CI, 0.86-1.67) for consumers of 0.1-4.9 g/day of alcohol, 1.90 (95% CI, 1.34-2.71) for consumers of 5-14.9 g/day, and 2.31 (95% CI, 1.54-3.46) for consumers of >= 15 g/day. The associations were consistent across the histologic subtypes of collagenous and lymphocytic colitis (P-heterogeneity = .523). When stratified by alcohol type, the risk according to every 2 servings/week appeared to be strongest with consumption of wine (aHR, 1.08; 95% CI, 1.04-1.12) as compared to beer (aHR, 1.01; 95% CI, 0.91-1.12) or liquor (aHR, 1.00; 95% CI, 0.92-1.09).Conclusions: Alcohol consumption was associated with an increased risk of MC. Further studies are needed to determine the mechanism underlying these associations, as well as the impact of reducing alcohol intake in patients with MC.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Casey, KevinDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA (författare)
  • Burke, KristinDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston MA, USA (författare)
  • Lopes, Emily W.Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston MA, USA (författare)
  • Lochhead, PaulDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston MA, USA (författare)
  • Ananthakrishnan, AshwinDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston MA, USA (författare)
  • Richter, James M.Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston MA, USA (författare)
  • Ludvigsson, Jonas F.,1969-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, UK; Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA(Swepub:oru)jsln (författare)
  • Chan, Andrew T.Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston MA, USA (författare)
  • Khalili, HamedDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston MA, USA; Institute of Environmental Medicine, Nutrition Epidemiology, Karolinska Institutet, Stockholm, Sweden; Broad Institute of MIT and Harvard, Cambridge MA, USA (författare)
  • Department of Internal Medicine, Massachusetts General Hospital, Boston MA, USADivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Inflammatory Bowel Diseases: Lippincott-Raven Publishers28:8, s. 1151-11591078-09981536-4844

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