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Sökning: onr:"swepub:oai:DiVA.org:oru-97895" > Umbilical cord bloo...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007261naa a2200553 4500
001oai:DiVA.org:oru-97895
003SwePub
008220309s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-978952 URI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Laajala, Essiu Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland; Turku Doctoral Programme of Molecular Medicine, University of Turku, Turku, Finland; Department of Computer Science, Aalto University, Espoo, Finland4 aut
2451 0a Umbilical cord blood DNA methylation in children who later develop type 1 diabetes
264 1b John Wiley & Sons,c 2021
338 a print2 rdacarrier
520 a Distinct DNA methylation patterns have recently been observed to precede Type 1 Diabetes in whole blood collected from young children. Our aim was to determine if such methylation patterns are present already at the time of birth. Reduced representation bisulfite sequencing (RRBS) analysis was performed on a unique collection of umbilical cord blood samples collected within the Type 1 Diabetes Prediction and Prevention (DIPP) study. Children later diagnosed with Type 1 Diabetes and/or testing positive for multiple islet autoantibodies (N=43) were compared to control individuals (N=79), who remained autoantibody‐negative throughout the DIPP follow‐up until 15 years of age. Altogether 24 clinical and technical covariates related to the pregnancy and the mother were included in a binomial mixed effects model, which was fit separately for each high‐coverage CpG site, followed by spatial and multiple testing adjustment of P values. We discovered a strong inflation of P values, which was caused by a standard spatial adjustment method. Findings that were based on Benjamini‐Hochberg corrected spatially adjusted P values, could not be validated by Pyrosequencing. We therefore used permutation‐based significance analysis and showed that sex‐associated differentially methylated cytosines could be reproducibly detected with this approach. After empirical type 1 error control, no differences in cord blood methylation patterns were observed between cases and controls. Differences between children who progress to Type 1 Diabetes and those who remain healthy throughout childhood, are not yet present in the perinatal DNA methylome.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653 a Autoimmunity
653 a diabetes
653 a molecular immunology
7001 a Ullah, Ubaidu Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland4 aut
7001 a Grönroos, Toniu Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland4 aut
7001 a Rasool, Omidu Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland4 aut
7001 a Aho, Viivi Hallau Department of Computer Science, Aalto University, Espoo, Finland4 aut
7001 a Konki, Mikkou Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland4 aut
7001 a Kattelus, Roosau Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland4 aut
7001 a Mykkänen, Juhau Research Centre of Applied and Preventive Cardiovascular Medicine, Institute of Biomedicine, University of Turku, Turku, Finland4 aut
7001 a Nurmio, Mirjau Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland4 aut
7001 a Mäkilä, Mari Vahäu Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland4 aut
7001 a Kallionpää, Hennau Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland4 aut
7001 a Lietzén, Niinau Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland4 aut
7001 a Laiho, Astau Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland4 aut
7001 a Hyöty, Heikkiu Department of Virology, Faculty of Medicine and Biosciences, University of Tampere, Tampere, Finland4 aut
7001 a Elo, Laura L.u Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland4 aut
7001 a Ilonen, Jormau Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland4 aut
7001 a Knip, Mikaelu Pediatric Research Center, Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Center for Child Health Research, Tampere University Hospital, Tampere, Finland4 aut
7001 a Lund, Riikka J.u Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland4 aut
7001 a Oresic, Matej,d 1967-u Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland4 aut0 (Swepub:oru)moc
7001 a Veijola, Riittau Department of Pediatrics, PEDEGO Research Unit, Medical Research Centre, Oulu, Finland4 aut
7001 a Lähdesmäki, Harriu Department of Computer Science, Aalto University, Espoo, Finland4 aut
7001 a Toppari, Jormau Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland; Department of Pediatrics, Turku University Hospital, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland4 aut
7001 a Lahesmaa, Riittau Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland4 aut
7102 a Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland; Turku Doctoral Programme of Molecular Medicine, University of Turku, Turku, Finland; Department of Computer Science, Aalto University, Espoo, Finlandb Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland4 org
7730 t European Journal of Immunologyd : John Wiley & Sonsg 51:Suppl. 1, s. 291-291q 51:Suppl. 1<291-291x 0014-2980x 1521-4141
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-97895

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