Sökning: onr:"swepub:oai:DiVA.org:oru-98538" > The role of ADHD ge...
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001 | oai:DiVA.org:oru-98538 | |
003 | SwePub | |
008 | 220412s2022 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:149227743 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-985382 URI |
024 | 7 | a https://doi.org/10.1038/s41398-022-01919-92 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1492277432 URI |
040 | a (SwePub)orud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Garcia-Argibay, Miguel,d 1988-u Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:oru)mlgy |
245 | 1 0 | a The role of ADHD genetic risk in mid-to-late life somatic health conditions |
264 | c 2022-04-11 | |
264 | 1 | b Nature Publishing Group,c 2022 |
338 | a print2 rdacarrier | |
500 | a Funding agencies:United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) R21MH116188 Estonian Research Council PSG615Correction: The role of ADHD genetic risk in mid-to-late life somatic health conditions. Garcia-Argibay, M., du Rietz, E., Lu, Y. et al. Transl Psychiatry 12, 166 (2022). https://doi.org/10.1038/s41398-022-01933-x | |
520 | a Growing evidence suggests that ADHD, an early onset neurodevelopmental disorder, is associated with poor somatic health in adulthood. However, the mechanisms underlying these associations are poorly understood. Here, we tested whether ADHD polygenic risk scores (PRS) are associated with mid-to-late life somatic health in a general population sample. Furthermore, we explored whether potential associations were moderated and mediated by life-course risk factors. We derived ADHD-PRS in 10,645 Swedish twins born between 1911 and 1958. Sixteen cardiometabolic, autoimmune/inflammatory, and neurological health conditions were evaluated using self-report (age range at measure 42-88 years) and clinical diagnoses defined by International Classification of Diseases codes in national registers. We estimated associations of ADHD-PRS with somatic outcomes using generalized estimating equations, and tested moderation and mediation of these associations by four life-course risk factors (education level, body mass index [BMI], tobacco use, alcohol misuse). Results showed that higher ADHD-PRS were associated with increased risk of seven somatic outcomes (heart failure, cerebro- and peripheral vascular disease, obesity, type 1 diabetes, rheumatoid arthritis, and migraine) with odds ratios ranging 1.07 to 1.20. We observed significant mediation effects by education, BMI, tobacco use, and alcohol misuse, primarily for associations of ADHD-PRS with cardiometabolic outcomes. No moderation effects survived multiple testing correction. Our findings suggests that higher ADHD genetic liability confers a modest risk increase for several somatic health problems in mid-to-late life, particularly in the cardiometabolic domain. These associations were observable in the general population, even in the absence of medical treatment for ADHD, and appear to be in part mediated by life-course risk factors. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
700 | 1 | a du Rietz, Ebbau Karolinska Institutet4 aut |
700 | 1 | a Lu, Yiu Karolinska Institutet4 aut |
700 | 1 | a Martin, Joannau Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK4 aut |
700 | 1 | a Haan, Elisu Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia4 aut |
700 | 1 | a Letho, Kelliu Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia4 aut |
700 | 1 | a Bergen, Sarah E.u Karolinska Institutet4 aut |
700 | 1 | a Lichtenstein, Paulu Karolinska Institutet4 aut |
700 | 1 | a Larsson, Henrik,d 1975-u Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:oru)hiln |
700 | 1 | a Brikell, Isabellu Karolinska Institutet4 aut |
710 | 2 | a Örebro universitetb Institutionen för medicinska vetenskaper4 org |
773 | 0 | t Translational Psychiatryd : Nature Publishing Groupg 12:1q 12:1x 2158-3188 |
856 | 4 | u https://doi.org/10.1038/s41398-022-01919-9y Fulltext |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-98538 |
856 | 4 8 | u https://doi.org/10.1038/s41398-022-01919-9 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:149227743 |
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