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Virchow's node meta...
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Wedin, M.,1977-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery
(författare)
Virchow's node metastasis from small intestinal neuroendocrine neoplasms : A bi-center cohort study
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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John Wiley & Sons,2022
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-98602
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-98602URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:vet swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Introduction: Small Intestinal Neuroendocrine Neoplasms (SI-NENs) may rarely metastasize to the left supraclavicular lymph nodes, also known as Virchow’s node metastasis (VM).Aim(s): Data on prevalence, prognostic significance and clinical course of disease for SI-NEN patients with VM is limited.Materials and methods: In this retrospective analysis of 231 SI-NEN patients treated at two tertiary referal centers we found nine patients with VM. We used a control group of 18 age-and sex-matched SI-NEN patients from the same cohort with stage IV disease, but no extrahepatic metastases.Results: VM prevalence was 3.9% (9/231; 5 females, median age at VM diagnosis 65 years). Two patients had G1, 5 G2 tumours and 2 of unspecified grade. Four patients presented with synchronous VM, whereas 3 developed metachronous VM after a median of 24 months (range: 4.8–117.6 months). Hepatic metastases were present in 7 patients, extrahepatic metastases (EM) in 8 (6 para-aortic distant lymph node metastases, 1 lung and 1 pancreatic metastasis) and peritoneal carcinomatosis in 2 patients. There was no difference in best-recorded responses to 1st line treatment according to RECIST 1.1 as well as progression-free (PFS) and overall survival rates (PFS) between patients with VM and those in the control group (Chi-square p=0.516; PFS: 71.7 vs. 106.9 months [95%CI 38.1-175.8]; log-rank p=0.855; OS: 138.6 [95%CI 17.2–260] vs. 109.9 [95%CI 91.7–128] months; log-rank p=0.533).Conclusion: VM is relatively rare in patients with SI-NENs. It is more often encountered in patients withG2 tumors and EM, mainly to distant para-aortic lymph nodes. Its presence does not seem to impact patients’ survival outcomes and treatment responses, when compared to age-and sex-matched patients with stage IV disease.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Tsoli, M.1st Department of Propaedeutic and Internal Medicine, Laiko University Hospital, National and Kapodistrian University of Athens, Athens, Greece
(författare)
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Wallin, G.,1952-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery(Swepub:oru)gwn
(författare)
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Janson, E. T.Department of Medical Sciences, Uppsala University, Uppsala, Sweden
(författare)
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Koumarianou, A.Hematology-Oncology Unit, Fourth Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
(författare)
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Kaltsas, G.1st Department of Propaupedic Internal Medicine, Endocrine Oncology Unit, Laiko Hospital, Athens, Greece
(författare)
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Daskalakis, K.,1979-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery(Swepub:oru)kds
(författare)
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Örebro universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of neuroendocrinology (Print): John Wiley & Sons34:Suppl. 1, s. 88-880953-81941365-2826
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Wedin, M., 1977-
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Tsoli, M.
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Wallin, G., 1952 ...
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Janson, E. T.
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Koumarianou, A.
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Kaltsas, G.
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Daskalakis, K., ...
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Örebro universitet