Sökning: onr:"swepub:oai:DiVA.org:oru-98602" > Virchow's node meta...
Fältnamn | Indikatorer | Metadata |
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000 | 04058naa a2200349 4500 | |
001 | oai:DiVA.org:oru-98602 | |
003 | SwePub | |
008 | 220419s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-986022 URI |
040 | a (SwePub)oru | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a vet2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Wedin, M.,d 1977-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery4 aut0 (Swepub:oru)mrwn |
245 | 1 0 | a Virchow's node metastasis from small intestinal neuroendocrine neoplasms :b A bi-center cohort study |
264 | 1 | b John Wiley & Sons,c 2022 |
338 | a print2 rdacarrier | |
520 | a Introduction: Small Intestinal Neuroendocrine Neoplasms (SI-NENs) may rarely metastasize to the left supraclavicular lymph nodes, also known as Virchow’s node metastasis (VM).Aim(s): Data on prevalence, prognostic significance and clinical course of disease for SI-NEN patients with VM is limited.Materials and methods: In this retrospective analysis of 231 SI-NEN patients treated at two tertiary referal centers we found nine patients with VM. We used a control group of 18 age-and sex-matched SI-NEN patients from the same cohort with stage IV disease, but no extrahepatic metastases.Results: VM prevalence was 3.9% (9/231; 5 females, median age at VM diagnosis 65 years). Two patients had G1, 5 G2 tumours and 2 of unspecified grade. Four patients presented with synchronous VM, whereas 3 developed metachronous VM after a median of 24 months (range: 4.8–117.6 months). Hepatic metastases were present in 7 patients, extrahepatic metastases (EM) in 8 (6 para-aortic distant lymph node metastases, 1 lung and 1 pancreatic metastasis) and peritoneal carcinomatosis in 2 patients. There was no difference in best-recorded responses to 1st line treatment according to RECIST 1.1 as well as progression-free (PFS) and overall survival rates (PFS) between patients with VM and those in the control group (Chi-square p=0.516; PFS: 71.7 vs. 106.9 months [95%CI 38.1-175.8]; log-rank p=0.855; OS: 138.6 [95%CI 17.2–260] vs. 109.9 [95%CI 91.7–128] months; log-rank p=0.533).Conclusion: VM is relatively rare in patients with SI-NENs. It is more often encountered in patients withG2 tumors and EM, mainly to distant para-aortic lymph nodes. Its presence does not seem to impact patients’ survival outcomes and treatment responses, when compared to age-and sex-matched patients with stage IV disease. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a virchow's node metastasis | |
653 | a small intestinal nen | |
700 | 1 | a Tsoli, M.u 1st Department of Propaedeutic and Internal Medicine, Laiko University Hospital, National and Kapodistrian University of Athens, Athens, Greece4 aut |
700 | 1 | a Wallin, G.,d 1952-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery4 aut0 (Swepub:oru)gwn |
700 | 1 | a Janson, E. T.u Department of Medical Sciences, Uppsala University, Uppsala, Sweden4 aut |
700 | 1 | a Koumarianou, A.u Hematology-Oncology Unit, Fourth Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece4 aut |
700 | 1 | a Kaltsas, G.u 1st Department of Propaupedic Internal Medicine, Endocrine Oncology Unit, Laiko Hospital, Athens, Greece4 aut |
700 | 1 | a Daskalakis, K.,d 1979-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery4 aut0 (Swepub:oru)kds |
710 | 2 | a Örebro universitetb Institutionen för medicinska vetenskaper4 org |
773 | 0 | t Journal of neuroendocrinology (Print)d : John Wiley & Sonsg 34:Suppl. 1, s. 88-88q 34:Suppl. 1<88-88x 0953-8194x 1365-2826 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-98602 |
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